ArticleJournal of clinical neurology (Seoul, Korea)2019
Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies.
Article in Journal of clinical neurology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Pooled it
- Is there a link between the use of benzodiazepines and related drugs and dementia? A systematic review of reviews.European geriatric medicine · 2022Pooled it
- Pooled it
- The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis of Comparative Studies.Frontiers in psychiatry · 2020Pooled it
- Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia.Frontiers in aging neuroscience · 2019Pooled it
- Non-pharmacological treatment of anxiety in general practice: a scoping review.Scandinavian journal of primary health care · 2026Article
- Multimorbidity, Polypharmacy, and Neighborhood Disadvantage as Determinants of Cognitive Performance in the ARCHES Cohort.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Prescription duration of benzodiazepines: a retrospective cohort study of prescription duration in primary care.European journal of clinical pharmacology · 2026Article
- Benzodiazepine Dependence: Clinical and Molecular Aspects, Preventive Strategies and Therapeutic Approaches.International journal of molecular sciences · 2026Review
- Review
- Efficacy of Taiji Stick exercise on sleep quality and anxiety in older adults: a randomized controlled trial.Frontiers in psychology · 2026Article
- Article
- Impact of cannabis use on health outcomes and prescription benzodiazepine use.medRxiv : the preprint server for health sciences · 2025Article
- Waste clearance shapes aging brain health.Neuron · 2025Review
- Synergistic effects of combined hypnotic drugs on sleep in mice.Frontiers in pharmacology · 2025Article
- Medication Exposure and Risk of Dementia and Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Article
- Incident traumatic spinal cord injury and risk of Alzheimer's disease and related dementia: longitudinal case and control cohort study.Spinal cord · 2024Article
- Optimising the use of electronic medical records for large scale research in psychiatry.Translational psychiatry · 2024Review
- Association Between Hypnotics and Dementia: A Mini Narrative Review.Psychiatry investigation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the long-term usage of BDZs and the risk of dementia.
methodsThe PubMed and Embase databases were systematically searched for relevant publications up to September 2017. The literature search focused on observational studies that analyzed the relationship between the long-term use of BDZs and the risk of dementia. Pooled rate ratios (RRs) with 95% confidence interval (CI) were assessed using a random-effects model. The robustness of the results was checked by performing subgroup and sensitivity analyses.
resultsTen studies were included: six case-control and four cohort studies. The pooled RR for developing dementia was 1.51 (95% CI=1.17-1.95,
conclusionsThis meta-analysis that pooled ten studies has shown that BDZ significantly increases the risk of dementia in the elderly population. The risk is higher in patients taking BDZ with a longer half-life (>20 hours) and for a longer duration (>3 years).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.