Evidence map›Paper›PMID 30375702›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Multiparametric MRI model with dynamic contrast-enhanced and diffusion-weighted imaging enables breast cancer diagnosis with high accuracy.

Michelle Zhang, Joao V Horvat, Blanca Bernard-Davila, Maria Adele Marino, Doris Leithner, R Elena Ochoa-Albiztegui, Thomas H Helbich, Elizabeth A Morris, Sunitha Thakur, Katja Pinker

Open access · hybridAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  9. Clinical Application of Artificial Intelligence in Breast MRI.Journal of the Korean Society of Radiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Michelle ZhangMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
Joao V HorvatMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
Blanca Bernard-DavilaMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
Maria Adele MarinoMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.ORCID 0000-0002-5614-2660
Doris LeithnerMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
R Elena Ochoa-AlbizteguiMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
Thomas H HelbichDepartment of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy.
Elizabeth A MorrisMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.
Sunitha ThakurMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.ORCID 0000-0001-8090-3696
Katja PinkerMemorial Sloan Kettering Cancer Center, Department of Radiology, Breast Imaging Service, NY, New York, USA.ORCID 0000-0002-2722-7331
Memorial Sloan Kettering Cancer Center · USUniversity of Messina · ITGoethe University Frankfurt · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe MRI Breast Imaging-Reporting and Data System (BI-RADS) lexicon recommends that a breast MRI protocol contain T PURPOSE/HYPOTHESIS: To develop a multiparametric MRI (mpMRI) model for breast cancer diagnosis incorporating American College of Radiology (ACR) BI-RADS recommended descriptors for breast MRI with DCE, T STUDY TYPE: Retrospective. SUBJECTS: In all, 188 patients (mean 51.6 years) with 210 breast tumors (136 malignant and 74 benign) who underwent mpMRI from December 2010 to September 2014. FIELD STRENGTH/SEQUENCE: IR inversion recovert DCE-MRI dynamic contrast-enhanced magnetic resonance imaging VIBE Volume-Interpolated-Breathhold-Examination FLASH turbo fast-low-angle-shot TWIST Time-resolved angiography with stochastic Trajectories. ASSESSMENT: Two radiologists in consensus and another radiologist independently evaluated the mpMRI data. Characteristics for mass (n = 182) and nonmass (n = 28) lesions were recorded on DCE and T STATISTICAL TESTS: χ

resultsIn Model 1, ADCmean (P = 0.0031), mass margins with DCE (P = 0.0016), and delayed enhancement with DCE (P = 0.0016) were significantly and independently associated with breast cancer diagnosis; Model 2 identified ADCmean (P = 0.0031), mass margins with DCE (P = 0.0012), initial enhancement (P = 0.0422), and delayed enhancement with DCE (P = 0.0065) to be significantly independently associated with breast cancer diagnosis. T LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:864-874.

Indexed as

Multiparametric Magnetic Resonance ImagingAgedBreast NeoplasmsContrast MediaFemaleHumansImage Processing, Computer-AssistedMiddle AgedObserver VariationReproducibility of ResultsRetrospective StudiesROC CurveSensitivity and SpecificityContrast MediaBI-RADSbreast cancerdiffusion-weighted imagingdynamic contrast-enhanced MRIT2-weighted imaging

Identifiers

PMID30375702
PMCPMC6375760
OpenAlexW2898948611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.