Trial reportScientific reports2018
Neuromodulation treats Chikungunya arthralgia: a randomized controlled trial.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Compounds from Natural Products Candidates to Drug for Chikungunya Virus Infection: A Systematic Review.Current drug targets · 2024Pooled it
- Contributions of musculoskeletal rehabilitation in patients after chikungunya fever: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Transcranial Direct Current Stimulation to Improve the Dysfunction of Descending Pain Modulatory System Related to Opioids in Chronic Non-cancer Pain: An Integrative Review of Neurobiology and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- From symptom management to immune prevention: a comprehensive review of chikungunya treatment and vaccine development.Folia microbiologica · 2026Review
- Methods of Computational Modelling in Studies of Transcranial Direct Current Stimulation (tDCS) in Adults to Inform Protocols for Tinnitus Treatment: A Scoping Review.Brain sciences · 2025Review
- Sedentary behavior, increasing age, and overweight/obesity increase the presence and intensity of the chronic joint pain in individuals affected by Chikungunya fever.Clinical rheumatology · 2024Article
- [Evidence map of chikungunya treatmentsMapa de la evidencia sobre el tratamiento del chikunguña].Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- Chikungunya fever.Nature reviews. Disease primers · 2023Review
- Article
- Transcranial direct current stimulation improves quality of life and physical fitness in diabetic polyneuropathy: a pilot double blind randomized controlled trial.Journal of diabetes and metabolic disorders · 2020Article
- Newer rehabilitation therapies: strategies in chikungunya chronic arthralgia.Clinical medicine (London, England) · 2020Article
- Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms.Frontiers in human neuroscience · 2020Review
- Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes.Journal of neuroengineering and rehabilitation · 2019Review
- Analysis of motor performance in individuals with cerebral palsy using a non-immersive virtual reality task - a pilot study.Neuropsychiatric disease and treatment · 2019Article
- Analysis of Different Device Interactions in a Virtual Reality Task in Individuals With Duchenne Muscular Dystrophy-A Randomized Controlled Trial.Frontiers in neurology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Chikungunya (CHIK) virus is epidemic in Brazil, with 170,000 cases in the first half of 2016. More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. There are no specific therapeutic agents to treat and rehabilitee infected persons with CHIK. Persistent pain can lead to incapacitation, requiring long-term pharmacological treatment. Advances in non-pharmacological treatments are necessary to promote pain relief without side effects and to restore functionality. Clinical trials indicate transcranial direct current stimulation (tDCS) can treat a broad range of chronic pain disorders, including diffuse neuromuscular pain and arthralgia. Here, we demonstrate that the tDCS across the primary motor cortex significantly reduces pain in the chronic phase of CHIK. High-resolution computational model was created to analyze the cortical electric field generated during tDCS and a diffuse and clustered brain current flow including M1 ipsilateral and contralateral, left DLPFC, nucleus accumbens, and cingulate was found. Our findings suggest tDCS could be an effective, inexpensive and deployable therapy to areas lacking resources with a significant number of patients with chronic CHIK persistent pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.