Evidence map›Paper›PMID 30375477›Full record

ArticleScientific reports2018

Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells.

Sara Amorim, Diana Soares da Costa, Daniela Freitas, Celso A Reis, Rui L Reis, Iva Pashkuleva, Ricardo A Pires

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

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  13. Acta pharmaceutica Sinica. B · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara Amorim3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.
Diana Soares da Costa3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.
Daniela FreitasInstituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, Porto, Portugal.
Celso A ReisInstituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0002-0286-6639
Rui L Reis3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal.ORCID http://orcid.org/0000-0002-4295-6129
Iva Pashkuleva3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal. pashkuleva@i3bs.uminho.pt.ORCID http://orcid.org/0000-0001-6818-3374
Ricardo A Pires3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal. rpires@i3bs.uminho.pt.
University of Minho · PTUniversidade do Porto · PT

Funding

USING VIRAL NANOPARTICLES TO TARGET CANCERR01CA112075 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MANCHESTER, MARIANNE · 2005 to 2009
$3.7M
EC | Horizon 2020 (European Union Framework Programme for Research and Innovation) H2020-TWINN-2015-692333-CHEM2NATUREEC | Horizon 2020 (European Union Framework Programme for Research and Innovation) H2020-TWINN-692333-CHEM2NATUREEC | Horizon 2020 (European Union Framework Programme for Research and Innovation) H2020-WIDESPREAD-2014-668983-FORECASTEC | Horizon 2020 (European Union Framework Programme for Research and Innovation) H2020-WIDESPREAD-668983-FORECASTEC | Horizon 2020 (European Union Framework Programme for Research and Innovation) H2020-WIDESPREAD-739572-THE DISCOVERIES CTRMinistry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) IF/00032/2013Ministry of Education and Science | Fundação para a Ciência e a Tecnologia (Portuguese Science and Technology Foundation) SFRH/BD/112075/2015
6 · The paper itself

Abstract

The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. However, these interactions are mainly studied in solution, whereas HA in the extracellular matrix (ECM) is partially immobilized via its interactions with other ECM components. We therefore, developed substrates in which HA is presented in an ECM-relevant manner. We immobilized HA with different molecular weights (M

Indexed as

Cell AdhesionCell Line, TumorCell MembraneCell MovementExtracellular MatrixHumansHyaluronan ReceptorsHyaluronic AcidMolecular WeightReceptors, Cell SurfaceStomach NeoplasmsSubstrate SpecificityHyaluronan ReceptorsHyaluronic AcidReceptors, Cell Surface

Identifiers

PMID30375477
PMCPMC6207784
OpenAlexW2898599332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.