ArticleNature communications2018
Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Sex-specific frontal cortical circuit mechanisms mediating fear extinction.bioRxiv : the preprint server for biology · 2026Article
- Distinct representational properties of cues and contexts shape fear and reversal learning.eLife · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Review
- Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.Molecular psychiatry · 2025Article
- Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans.Communications biology · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Activation patterns in male and female forebrain areas during habituation to food and context novelty.Brain structure & function · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- Repeated social defeat in male mice induced unique RNA profiles in projection neurons from the amygdala to the hippocampus.Brain, behavior, & immunity - health · 2025Article
- Article
- The Spiraling Cognitive-Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization.Journal of cognitive neuroscience · 2024Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The thalamic nucleus reuniens (RE) receives dense projections from the medial prefrontal cortex (mPFC), interconnects the mPFC and hippocampus, and may serve a pivotal role in regulating emotional learning and memory. Here we show that the RE and its mPFC afferents are critical for the extinction of Pavlovian fear memories in rats. Pharmacological inactivation of the RE during extinction learning or retrieval increases freezing to an extinguished conditioned stimulus (CS); renewal of fear outside the extinction context was unaffected. Suppression of fear in the extinction context is associated with an increase in c-fos expression and spike firing in RE neurons to the extinguished CS. The role for the RE in suppressing extinguished fear requires the mPFC, insofar as pharmacogenetically silencing mPFC to RE projections impairs the expression of extinction memory. These results reveal that mPFC-RE circuits inhibit the expression of fear, a function that is essential for adaptive emotional regulation.
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