Evidence map›Paper›PMID 30375394›Full record

ArticleNature communications2018

The DNA binding landscape of the maize AUXIN RESPONSE FACTOR family.

Mary Galli, Arjun Khakhar, Zefu Lu, Zongliang Chen, Sidharth Sen, Trupti Joshi, Jennifer L Nemhauser, Robert J Schmitz, Andrea Gallavotti

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Biology · 2026
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  15. aBIOTECH · 2025
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  20. A conserved ARF-DNA interface underlies auxin-triggered transcriptional response.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mary GalliWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ, 08854-8020, USA.
Arjun KhakharDepartment of Biology, University of Washington, Seattle, WA, 98195-1800, USA.
Zefu LuDepartment of Genetics, The University of Georgia, Athens, GA, 30602, USA.
Zongliang ChenWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ, 08854-8020, USA.
Sidharth SenInformatics Institute, University of Missouri, Columbia, MO, 65211, USA.ORCID http://orcid.org/0000-0002-9196-204X
Trupti JoshiInformatics Institute, University of Missouri, Columbia, MO, 65211, USA.
Jennifer L NemhauserDepartment of Biology, University of Washington, Seattle, WA, 98195-1800, USA.
Robert J SchmitzDepartment of Genetics, The University of Georgia, Athens, GA, 30602, USA.
Andrea GallavottiWaksman Institute of Microbiology, Rutgers University, Piscataway, NJ, 08854-8020, USA. agallavotti@waksman.rutgers.edu.ORCID http://orcid.org/0000-0002-1901-2971

Funding

National Science Foundation (NSF) IOS-1546867National Science Foundation (NSF) IOS-1546873
6 · The paper itself

Abstract

AUXIN RESPONSE FACTORS (ARFs) are plant-specific transcription factors (TFs) that couple perception of the hormone auxin to gene expression programs essential to all land plants. As with many large TF families, a key question is whether individual members determine developmental specificity by binding distinct target genes. We use DAP-seq to generate genome-wide in vitro TF:DNA interaction maps for fourteen maize ARFs from the evolutionarily conserved A and B clades. Comparative analysis reveal a high degree of binding site overlap for ARFs of the same clade, but largely distinct clade A and B binding. Many sites are however co-occupied by ARFs from both clades, suggesting transcriptional coordination for many genes. Among these, we investigate known QTLs and use machine learning to predict the impact of cis-regulatory variation. Overall, large-scale comparative analysis of ARF binding suggests that auxin response specificity may be determined by factors other than individual ARF binding site selection.

Indexed as

Gene Expression Regulation, PlantDNAQuantitative Trait LociTranscription FactorsZea maysDNATranscription Factors

Identifiers

PMID30375394
PMCPMC6207667

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.