ArticleNature communications2018
Adrenal hormones mediate disease tolerance in malaria.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A systematic review and meta-analysis of cortisol levels in Plasmodium infections.Scientific reports · 2024Pooled it
- Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism.The EMBO journal · 2026Article
- Malaria vaccines: Current developments and immunological insights.New microbes and new infections · 2025Article
- Systems Biological Analysis of Immune-Metabolic Host Responses to Distinct Malaria Parasites.ACS omega · 2025Article
- JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation.EMBO molecular medicine · 2025Article
- A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses.Nature communications · 2025Article
- Coinfection of COVID-19 and malaria: clinical profiles, interactions, and strategies for effective control.Malaria journal · 2025Review
- The differential effect of Interferon-gamma on acute kidney injury and parasitemia in experimental malaria.Scientific reports · 2025Article
- Adrenergic signaling during parasitic infections.Frontiers in immunology · 2025Review
- MicroRNA Guided In Silico Drug Repositioning for Malaria.Acta parasitologica · 2024Article
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Uncovering the diversity of pathogenic invaders: insights into protozoa, fungi, and worm infections.Frontiers in microbiology · 2024Review
- Glucocorticoid dysfunction in children with severe malaria.Frontiers in immunology · 2023Article
- Cell-Specific Immune Regulation by Glucocorticoids in Murine Models of Infection and Inflammation.Cells · 2022Review
- Hypothyroidism confers tolerance to cerebral malaria.Science advances · 2022Article
- Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment.Frontiers in cellular and infection microbiology · 2022Article
- CCR6 expression reduces mouse survival upon malarial challenge with Plasmodium berghei NK65 strain.Memorias do Instituto Oswaldo Cruz · 2022Article
- Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation.PLoS neglected tropical diseases · 2021Article
- Dexamethasone increased the survival rate in Plasmodium berghei-infected mice.Scientific reports · 2021Article
- Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity.iScience · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Malaria reduces host fitness and survival by pathogen-mediated damage and inflammation. Disease tolerance mechanisms counter these negative effects without decreasing pathogen load. Here, we demonstrate that in four different mouse models of malaria, adrenal hormones confer disease tolerance and protect against early death, independently of parasitemia. Surprisingly, adrenalectomy differentially affects malaria-induced inflammation by increasing circulating cytokines and inflammation in the brain but not in the liver or lung. Furthermore, without affecting the transcription of hepatic gluconeogenic enzymes, adrenalectomy causes exhaustion of hepatic glycogen and insulin-independent lethal hypoglycemia upon infection. This hypoglycemia is not prevented by glucose administration or TNF-α neutralization. In contrast, treatment with a synthetic glucocorticoid (dexamethasone) prevents the hypoglycemia, lowers cerebral cytokine expression and increases survival rates. Overall, we conclude that in malaria, adrenal hormones do not protect against lung and liver inflammation. Instead, they prevent excessive systemic and brain inflammation and severe hypoglycemia, thereby contributing to tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.