SynthesisTranslational psychiatry2018
Subclinical hypothyroidism and depression: a meta-analysis.
Synthesis in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Evaluating cardiac echocardiographic changes with levothyroxine in hypothyroid patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Thyroid-Stimulating Hormone Levels and Depression in Older Adults: Cross-Sectional and Longitudinal Analyses in a Community-Dwelling Population.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Trial
- Thyroid Dysfunction and the Risk of Clinically Relevant Depression: A Longitudinal Cohort Study.Mayo Clinic proceedings · 2026Article
- The association between thyroid hormone levels and psychiatric symptoms in patients with mania or depression.Endocrine journal · 2026Article
- Expressive pragmatic language in mood and psychotic disorders: a systematic review and meta-analysis.Schizophrenia (Heidelberg, Germany) · 2026Review
- The Association of Thyroid Function on Cognition and Neuropsychiatric Symptoms in Patients with Cognitive Impairment.Neuropsychiatric disease and treatment · 2026Article
- Prevalence of thyroid dysfunction in psychiatric inpatients: A cross sectional prevalence study.Bioinformation · 2026Article
- The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: focus on clinical, pre-clinical and molecular studies.European thyroid journal · 2025Review
- The Association Between Thyrotropin and Clinically Relevant Depression: A Retrospective Cross-Sectional Study.Thyroid : official journal of the American Thyroid Association · 2025Article
- Prevalence and Risk Factors of Subclinical Hypothyroidism in Young and Middle-Aged Patients With First-Episode Drug-Naïve Major Depressive Disorder.Depression and anxiety · 2025Article
- Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress.Developmental biology · 2024Article
- Investigating thyroid function and iodine status in adolescents with and without paediatric major depressive disorder.The British journal of nutrition · 2024Article
- Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study.Brain and behavior · 2024Article
- Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder.BMC geriatrics · 2024Article
- The association between depression and thyroid function.Frontiers in endocrinology · 2024Article
- Lack of Association Between Depression and Subclinical Hypothyroidism in Adolescents Presenting for Routine Physical Examinations.Clinical medicine insights. Pediatrics · 2024Article
- Trace Elements Levels in Major Depressive Disorder-Evaluation of Potential Threats and Possible Therapeutic Approaches.International journal of molecular sciences · 2023Review
- Lifestyle and Quality of Life of Women with Diagnosed Hypothyroidism in the Context of Metabolic Disorders.Metabolites · 2023Article
- Association of Low-Normal Free T4 Levels With Future Major Depression Development.Journal of the Endocrine Society · 2023Article
- The Association Between Thyroid Stimulating Hormone and Depression: A Historical Cohort Study.Mayo Clinic proceedings · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the relationship between subclinical hypothyroidism (SCH) and depression. We also analysed the effect of levothyroxine (L-T4) on depression in SCH patients. We found an insignificant difference for the composite endpoint: standard mean difference (SMD) of 0.23 (95% confidence interval (CI) -0.03, 0.48, P = 0.08, I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.