Evidence map›Paper›PMID 30375330›Full record

ArticleeLife2018

Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue.

Natalie Jing Ma, Colin F Hemez, Karl W Barber, Jesse Rinehart, Farren J Isaacs

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Genomically recodedbioRxiv : the preprint server for biology · 2024
    Article
  5. Synthetic genomes unveil the effects of synonymous recoding.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. RNA biology · 2023
    Article
  11. Article
  12. Article
  13. How To Quantify a Genetic Firewall? A Polarity-Based Metric for Genetic Code Engineering.Chembiochem : a European journal of chemical biology · 2021
    Article
  14. Article
  15. Building genomes to understand biology.Nature communications · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalie Jing Ma *Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-7452-9482
Colin F Hemez *Systems Biology Institute, Yale University, West Haven, United States.ORCID 0000-0003-3445-7706
Karl W Barber *Systems Biology Institute, Yale University, West Haven, United States.ORCID 0000-0003-0672-8409
Jesse RinehartSystems Biology Institute, Yale University, West Haven, United States.
Farren J IsaacsDepartment of Molecular, Cellular & Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-8615-8236

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
Revealing substrates and phosphoproteome level function of human STE20 kinasesR01GM117230 · NIGMS · YALE UNIVERSITY · PI ISAACS, FARREN J., RINEHART, JESSE · 2015 to 2024
$3.2M
Expanding the genetic code with phosphotyrosine and phosphothreonineR01GM125951 · NIGMS · YALE UNIVERSITY · PI ISAACS, FARREN J., RINEHART, JESSE · 2018 to 2021
$1.2M
Arnold and Mabel Beckman Foundation Beckman Scholar AwardArnold and Mabel Beckman Foundation Young Investigator AwardDefense Advanced Research Projects Agency HR0011-15-C-0091Defense Advanced Research Projects Agency N66001-12-C-4211DuPont Young Professor AwardGruber Foundation Graduate Research FellowshipNational Science Foundation Graduate Research Fellowship DGE-1122492NIGMS NIH HHS R01 GM117230NIGMS NIH HHS R01 GM125951NIGMS NIH HHS T32 GM007223NIGMS NIH HHS T32 GM007499NIH HHS Graduate Training Grants T32GM007499,T32GM007223NIH HHS R01GM117230NIH HHS R01GM125951U.S. Department of Energy 152339.5055249.100
6 · The paper itself

Abstract

Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer. Here, we use a genomically recoded

Indexed as

Codon, TerminatorEscherichia coliEscherichia coli ProteinsFrameshifting, RibosomalGene Expression Regulation, BacterialGenetic CodeGene Transfer, HorizontalGenome, BacterialPlasmidsRNA, BacterialRNA-Binding ProteinsVirusesArfA protein, E coliCodon, TerminatorEscherichia coli ProteinsRNA, BacterialRNA-Binding ProteinstmRNAE. coligenetic codegeneticsgenomicshorizontal gene transferinfectious diseasemicrobiologyribosomal stallingribosome rescuetranslationviral resistancevirus

Identifiers

PMID30375330
PMCPMC6207430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.