ArticleDeutsches Arzteblatt international2018
The Diagnosis and Treatment of Penile Cancer.
Article in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Effects of partial penectomy for penile cancer on sexual function: A systematic review.PloS one · 2022Pooled it
- Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.International journal of molecular sciences · 2021Pooled it
- Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature.International journal of environmental research and public health · 2021Pooled it
- Malignant Priapism as the Sole Initial Manifestation of Metastatic Carcinoma with Suspected Pulmonary Origin: A Case Report and Review of the Literature.Reports (MDPI) · 2026Article
- Clinical Presentation and Surgical Management of Penile Carcinoma: A Retrospective Case Series from a Tertiary Referral Center.Diagnostics (Basel, Switzerland) · 2026Article
- Retrospective single-center cytohistologic correlation study of fine-needle aspiration cytology for excised superficial enlarged lymph node lesions in different disease entities.Discover oncology · 2026Article
- Survivin and Ki-67 immunohistochemical expression in penile squamous cell carcinoma: clinicopathological features and overall survival.International urology and nephrology · 2026Article
- [Current diagnostics and treatment of penile cancer].Urologie (Heidelberg, Germany) · 2026Review
- Prediction of distant metastases in penile squamous cell carcinoma: a SEER population-based study.International urology and nephrology · 2026Article
- Penile involvement associated with renal pelvic squamous cell carcinoma: a case report and mechanistic considerations.Frontiers in oncology · 2026Article
- Systemic Chemotherapy in Penile Squamous Cell Carcinoma: Mechanisms, Clinical Applications, and Evidence-Based Regimens.Cancers · 2025Review
- [Centralization or individualization in penile cancer care : Evidence, international insights, and a future framework for Germany].Urologie (Heidelberg, Germany) · 2025Article
- The impact of diagnosis and treatment of penile cancer on intimacy: a qualitative assessment.International journal of impotence research · 2025Article
- Patient-reported outcome measures in penile cancer: a narrative review.International journal of impotence research · 2025Review
- Penile cancer treatment and sexuality: a narrative review.International journal of impotence research · 2025Review
- Emerging nanotherapeutics for HPV-associated cancers: current advances, challenges, and future directions.Discover oncology · 2025Review
- Identification of new tissue markers for the monitoring and standardization of penile cancer according to the degree of differentiation.Histology and histopathology · 2025Article
- Predictors of Inguinal Lymph Node Metastasis in Penile Squamous Cell Carcinoma: Insights from a Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- AssessingNuclear medicine and molecular imaging · 2025Article
- Comprehensive assessment in uro-oncologic geriatric patients: interdisciplinary management to improve survival.International urology and nephrology · 2025Review
32 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of penile cancer in Europe lies in the range of 0.9 to 2.1 cases per 100 000 persons per year. Carcinogenesis is associated with human papilloma virus (HPV) infection and with chronic inflammation.
methodsThis review is based on publications (2010-2017) retrieved by a selective search in PubMed and EMBASE and on the guidelines of the European Association of Urology, the European Society of Medical Oncology, the National Comprehensive Cancer Network, and the National Institute for Health and Care Excellence (NICE).
results95% of cases of penile cancer are accounted for by squamous cell carcinoma, whose numerous subtypes have different clinical courses. Chronic preputial inflammation due to phimosis or lichen sclerosus is often associated with penile cancer. Circumcision lowers the risk of penile cancer (hazard ratio: 0.33). Maximally organ-preserving surgery with safety margins of no more than a few millimeters is the current therapeutic standard, because a local recurrence, if it arises, can still be treated locally with curative intent. Local radiotherapy can be performed in early stages. Lymphogenic metastasis must be treated with radical lymphadenectomy and adjuvant chemotherapy. Patients with clinically unremarkable inguinal lymph nodes nonetheless need invasive lymph node staging because of the high rate of lymphogenic micrometastasis.
conclusionPenile cancer is curable in all early stages with the appropriate treatment, but its prognosis depends crucially on the proper management of the regional (i.e., inguinal) lymph nodes. In many countries, the treatment of this rare disease entity has been centralized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.