SynthesisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
A systematic review on the quantitative relationship between structural and functional network connectivity strength in mammalian brains.
Synthesis in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the relationship between magnetic resonance imaging based resting-state and structural networks in the rodent brain.Frontiers in neuroscience · 2023Pooled it
- Language reorganization in brain arteriovenous malformations with fiber-based regional functional connectivity.Magnetic resonance letters · 2027Article
- Individualized parcellation reveals functional boundaries in human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Altered neurovascular coupling in patients with human immunodeficiency virus-associated asymptomatic neurocognitive impairment: a multimodal magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.PLoS computational biology · 2026Article
- Distinct functional connectivity patterns in myalgic encephalomyelitis and long COVID patients during cognitive fatigue: a 7 Tesla task-fMRI study.Journal of translational medicine · 2026Article
- Gene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability.Nature communications · 2025Article
- Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered putamen connectivity in patients with neurological post-COVID condition.Brain communications · 2025Article
- Audiovisual integration and whole-brain networks in preterm and full-term neonates: A two-layer multiplex network perspective on structural and functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Computational modeling of resistance to hormone-mediated remission in childhood absence epilepsy.Frontiers in computational neuroscience · 2025Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- Structure-function coupling in highly sampled individual brains.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A within-subject voxel-wise constant-block partial least squares correlation method to explore MRI-based brain structure-function relationship.Cognitive neurodynamics · 2024Article
- Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.PLoS computational biology · 2024Article
- Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.Communications biology · 2024Article
- ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.NeuroImage. Clinical · 2024Review
- Structural basis of envelope and phase intrinsic coupling modes in the cerebral cortex.NeuroImage · 2023Article
- The fractal brain: scale-invariance in structure and dynamics.Cerebral cortex (New York, N.Y. : 1991) · 2023Review
- Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian brain is composed of densely connected and interacting regions, which form structural and functional networks. An improved understanding of the structure-function relation is crucial to understand the structural underpinnings of brain function and brain plasticity after injury. It is currently unclear how functional connectivity strength relates to structural connectivity strength. We obtained an overview of recent papers that report on correspondences between quantitative functional and structural connectivity measures in the mammalian brain. We included network studies in which functional connectivity was measured with resting-state fMRI, and structural connectivity with either diffusion-weighted MRI or neuronal tract tracers. Twenty-seven of the 28 included studies showed a positive structure-function relationship. Large inter-study variations were found comparing functional connectivity strength with either quantitative diffusion-based (correlation coefficient (r) ranges: 0.18-0.82) or neuronal tracer-based structural connectivity measures (r = 0.24-0.74). Two functional datasets demonstrated lower structure-function correlations with neuronal tracer-based (r = 0.22 and r = 0.30) than with diffusion-based measures (r = 0.49 and r = 0.65). The robust positive quantitative structure-function relationship supports the hypothesis that structural connectivity provides the hardware from which functional connectivity emerges. However, methodological differences between the included studies complicate the comparison across studies, which emphasize the need for validation and standardization in brain structure-function studies.
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