Evidence map›Paper›PMID 30375184›Full record

ArticleGenes, brain, and behavior2019

A novel role for acid-sensing ion channels in Pavlovian reward conditioning.

Ali Ghobbeh, Rebecca J Taugher, Syed M Alam, Rong Fan, Ryan T LaLumiere, John A Wemmie

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Identification and analgesic activity study of analgesic protein Ⅶ-2 fromThe journal of venomous animals and toxins including tropical diseases · 2024
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali GhobbehDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-9276-4742
Rebecca J TaugherDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-6710-984X
Syed M AlamDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.
Rong FanDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.
Ryan T LaLumiereDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.
John A WemmieDepartment of Psychiatry, University of Iowa, Iowa City, Iowa.

Funding

The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)T32MH019113 · NIMH · UNIVERSITY OF IOWA · PI HANNA E STEVENS, John A Wemmie · 1991 to 2026
$5.6M
Regulation of Cerebral Blood Flow by Acid-Sensing Ion Channels (ASICs)R01HL113863 · NHLBI · UNIVERSITY OF IOWA · PI FARACI, FRANK M, WEMMIE, JOHN A · 2012 to 2016
$1.9M
Modeling CO2-evoked fear in mice: role of acid-sensing ion channelsR01MH085724 · NIMH · UNIVERSITY OF IOWA · PI WEMMIE, JOHN A · 2009 to 2013
$1.8M
Modulation of Synaptic and Behavioral Measures of Addiction by Acid-sensing Ion ChannelsR01DA037216 · NIDA · UNIVERSITY OF IOWA · PI LALUMIERE, RYAN T, WEMMIE, JOHN A · 2014 to 2018
$1.8M
Basolateral amygdala circuits in defensive behavior regulationR01MH113325 · NIMH · UNIVERSITY OF IOWA · PI WEMMIE, JOHN A · 2018 to 2022
$1.8M
Brain pH and Acid Sensing in Depression-Related BehaviorI01BX000741 · VA · IOWA CITY VA MEDICAL CENTER · PI WEMMIE, JOHN A · 2011 to 2018
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BLRD VA I01 BX000741BLRD VA I01 BX004440NHLBI NIH HHS R01 HL113863NHLBI NIH HHS R01HL113863NIDA NIH HHS R01 DA037216NIMH NIH HHS 5R01MH085724NIMH NIH HHS 5T32MH019113NIMH NIH HHS R01 MH085724NIMH NIH HHS R01 MH113325NIMH NIH HHS T32 MH019113
6 · The paper itself

Abstract

Pavlovian fear conditioning has been shown to depend on acid-sensing ion channel-1A (ASIC1A); however, it is unknown whether conditioning to rewarding stimuli also depends on ASIC1A. Here, we tested the hypothesis that ASIC1A contributes to Pavlovian conditioning to a non-drug reward. We found effects of ASIC1A disruption depended on the relationship between the conditional stimulus (CS) and the unconditional stimulus (US), which was varied between five experiments. In experiment 1, when the CS preceded the US signaling an upcoming reward, Asic1a

Indexed as

Conditioning, ClassicalRewardAcid Sensing Ion ChannelsAnimalsFearFemaleGene DeletionMaleMiceMice, Inbred C57BLAcid Sensing Ion ChannelsASIC1 protein, mouseASIC1Alearning and memoryPavlovianreward

Identifiers

PMID30375184
PMCPMC6818262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.