ArticleMolecular ecology2019
Genomic signatures of experimental adaptive radiation in Drosophila.
Article in Molecular ecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Quantifying the Evolutionary Potential for Delta Smelt Persistence in a Warming Habitat.Evolutionary applications · 2026Article
- Quantifying the evolutionary potential for Delta Smelt persistence in a warming habitat.bioRxiv : the preprint server for biology · 2026Article
- PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium.Genome biology and evolution · 2026Article
- Postnatal temperature triggers predictable thermoregulatory shifts in birds without a trade-off between heat and cold tolerance.The Journal of experimental biology · 2026Article
- Evolutionary Dynamics of Gene Expression During Thermal Adaptation in Drosophila subobscura.Genome biology and evolution · 2026Article
- Pervasive sex-dependent effects in the genetic architecture of starvation resistance inScience advances · 2025Article
- Experimental Evolution in a Warming World: The Omics Era.Molecular biology and evolution · 2024Review
- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- Artificial selection reveals complex genetic architecture of shoot branching and its response to nitrate supply in Arabidopsis.PLoS genetics · 2023Article
- Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity.bioRxiv : the preprint server for biology · 2023Article
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Evolutionary trade-offs between heat and cold tolerance limit responses to fluctuating climates.Science advances · 2022Article
- Genome-wide evolutionary response of European oaks during the Anthropocene.Evolution letters · 2022Article
- Crossing design shapes patterns of genetic variation in synthetic recombinant populations of Saccharomyces cerevisiae.Scientific reports · 2021Article
- The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime.Genome biology · 2021Article
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
- Experimental evolution supports signatures of sexual selection in genomic divergence.Evolution letters · 2021Article
- An Experimental Test of Adaptive Introgression in Locally Adapted Populations of Splash Pool Copepods.Molecular biology and evolution · 2021Article
- Next-generation biological control: the need for integrating genetics and genomics.Biological reviews of the Cambridge Philosophical Society · 2020Review
- Low concordance of short-term and long-term selection responses in experimental Drosophila populations.Molecular ecology · 2020Article
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5 authors at 4 institutions in 3 countries.
Funding
Abstract
Abiotic environmental factors play a fundamental role in determining the distribution, abundance and adaptive diversification of species. Empowered by new technologies enabling rapid and increasingly accurate examination of genomic variation in populations, researchers may gain new insights into the genomic background of adaptive radiation and stress resistance. We investigated genomic variation across generations of large-scale experimental selection regimes originating from a single founder population of Drosophila melanogaster, diverging in response to ecologically relevant environmental stressors: heat shock, heat knock down, cold shock, desiccation and starvation. When compared to the founder population, and to parallel unselected controls, there were more than 100,000 single nucleotide polymorphisms (SNPs) displaying consistent allelic changes in response to selective pressures across generations. These SNPs were found in both coding and noncoding sequences, with the highest density in promoter regions, and involved a broad range of functionalities, including molecular chaperoning by heat-shock proteins. The SNP patterns were highly stressor-specific despite considerable variation among line replicates within each selection regime, as reflected by a principal component analysis, and co-occurred with selective sweep regions. Only ~15% of SNPs with putatively adaptive changes were shared by at least two selective regimes, while less than 1% of SNPs diverged in opposite directions. Divergent stressors driving evolution in the experimental system of adaptive radiation left distinct genomic signatures, most pronounced in starvation and heat-shock selection regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.