Evidence map›Paper›PMID 30374952›Full record

ArticleBritish journal of pharmacology2019

Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats.

Madhurima Singh, Stefanie Bittner, Yihang Li, Alex Bittner, Lu Han, Yuan Cortez, Mohammed Inayathullah, Zeeshan Arif, Ramakrishnan Parthasarathi, Jayakumar Rajadas and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Madhurima SinghGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Stefanie BittnerGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Yihang LiGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Alex BittnerGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Lu HanGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Yuan CortezGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Mohammed InayathullahDivision of Cardiovascular Pharmacology CVI, BioADD Laboratory, Stanford, CA, USA.ORCID 0000-0001-7646-1709
Zeeshan ArifComputational Toxicology Facility, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
Ramakrishnan ParthasarathiComputational Toxicology Facility, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
Jayakumar RajadasDivision of Cardiovascular Pharmacology CVI, BioADD Laboratory, Stanford, CA, USA.
Wen-Jun ShenGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0001-5150-1698
Mark R NicollsGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Fredric B KraemerGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Salman AzharGeriatric Research, Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI HASSAN CHAIB · 2017 to 2026
$19.5M
Hypo-Lipidemic Actions of Creosote Bush-Derived NDGAR01HL092473 · NHLBI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI AZHAR, SALMAN · 2009 to 2013
$1.8M
LipolysisI01BX000398 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI KRAEMER, FREDRIC B. · 2009 to 2020
–
Role of Cholesterol in Age-related Decline in SteroidogenesisI01BX001923 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI AZHAR, SALMAN · 2013 to 2020
–
BLRD VA I01 BX000398BLRD VA I01 BX001923NHLBI NIH HHS R01 HL092473NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

background and purposePrevious studies have shown that Creosote bush-derived nordihydroguaiaretic acid (NDGA) exerts beneficial actions on the key components of metabolic syndrome including dyslipidaemia, insulin resistance and hypertension in several relevant rodent models. Here, we synthesized and screened a total of 6 anti-hyperlipidaemic analogues of NDGA and tested their efficacy against hepatic lipid metabolism in a high-fructose diet (HFrD) fed dyslipidaemic rat model. EXPERIMENTAL APPROACH: HFrD fed Sprague-Dawley rats treated with NDGA or one of the six analogues were used. Serum samples were analysed for blood metabolites, whereas liver samples were quantified for changes in various mRNA levels by real-time RT-PCR. KEY

resultsOral gavage of HFrD-fed rats for 4 days with NDGA analogues 1 and 2 (100 mg·kg CONCLUSIONS AND IMPLICATIONS: Our data suggest that NDGA analogues 1, 2, 4 and 5, particularly analogue 4, exert their anti-hyperlipidaemic actions by negatively targeting genes of key enzymes and transcription factors involved in lipogenesis, triglyceride synthesis and fatty acid elongation. These analogues have therapeutic potential.

Indexed as

AnimalsHyperlipidemiasHypolipidemic AgentsMaleMasoprocolMolecular Docking SimulationMolecular StructureRatsRats, Sprague-DawleyHypolipidemic AgentsMasoprocol

Identifiers

PMID30374952
PMCPMC6329620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.