ArticleNucleic acids research1987
Human cardiac myosin heavy chain genes and their linkage in the genome.
Article in Nucleic acids research, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 165 citations in OpenAlex.
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Expression of MyHC-15 and -2x in human muscle spindles: An immunohistochemical study.Journal of anatomy · 2023Article
- Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Review
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive physiology · 2019Review
- The ancient sarcomeric myosins found in specialized muscles.Skeletal muscle · 2019Review
- Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype.Frontiers in physiology · 2016Review
- The genetic basis of hypertrophic cardiomyopathy in cats and humans.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2015Review
- Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene.BMC evolutionary biology · 2013Article
- Autoimmune myocarditis, valvulitis, and cardiomyopathy.Current protocols in immunology · 2013Article
- Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history.Circulation research · 2011Review
- The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1.The Journal of experimental biology · 2010Article
- Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Differential regulation of the myosin heavy chain genes alpha and beta in rat atria and ventricles: role of antisense RNA.Thyroid : official journal of the American Thyroid Association · 2008Article
- Thick and thin filament gene mutations in striated muscle diseases.International journal of molecular sciences · 2008Article
- Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure.Journal of molecular and cellular cardiology · 2007Review
- Cluster characterisation and temporal expression of porcine sarcomeric myosin heavy chain genes.Journal of muscle research and cell motility · 2003Article
- Dynamic nature of fibre-type specific expression of myosin heavy chain transcripts in 14 different human skeletal muscles.Journal of muscle research and cell motility · 2001Article
- Dominant hereditary inclusion-body myopathy gene (IBM3) maps to chromosome region 17p13.1.American journal of human genetics · 1999Article
- Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Human myosin heavy chains are encoded by a multigene family consisting of at least 10 members. A gene-specific oligonucleotide has been used to isolate the human beta myosin heavy chain gene from a group of twelve nonoverlapping genomic clones. We have shown that this gene (which is expressed in both cardiac and skeletal muscle) is located 3.6kb upstream of the alpha cardiac myosin gene. We find that DNA sequences located upstream of rat and human alpha cardiac myosin heavy chain genes are very homologous over a 300bp region. Analogous regions of two other myosin genes expressed in different muscles (cardiac and skeletal) show no such homology to each other. While a human skeletal muscle myosin heavy chain gene cluster is located on chromosome 17, we show that the beta and alpha human cardiac myosin heavy chain genes are located on chromosome 14.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.