ArticleEating and weight disorders : EWD2018
Predictors of the transition from metabolically healthy obesity to unhealthy obesity.
Article in Eating and weight disorders : EWD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association Between Hepatic Steatosis and Deterioration of Metabolic Health in Obese Individuals: A 12-Year Follow-Up of the Tehran Lipid and Glucose Study.Endocrinology, diabetes & metabolism · 2026Article
- Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state.Diabetes, obesity & metabolism · 2025Article
- Metabolically healthy versus unhealthy obese phenotypes in relation to hypertension incidence; a prospective cohort study.BMC cardiovascular disorders · 2022Article
- Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus?World journal of diabetes · 2022Review
- The Interaction Between Dietary Total Antioxidant Capacity and MC4R Gene and HOMA-IR in Metabolically Healthy and Unhealthy Overweight and Obese Women.Nutrition and metabolic insights · 2022Article
- BMI, high-sensitivity C-reactive protein and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults: a cohort study.Public health nutrition · 2021Article
- Prediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study.Phenomics (Cham, Switzerland) · 2021Article
- Obesity paradox and aging.Eating and weight disorders : EWD · 2021Review
- Short-Term Changes in Metabolically Healthy Overweight/Obesity Status Impact the Susceptibility to Type 2 Diabetes in Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study.International journal of environmental research and public health · 2020Article
- Categorization of β-cell capacity in patients with obesity via OGTT using K-means clustering.Endocrine connections · 2020Article
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5 authors.
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Abstract
purposeEvidence that metabolically healthy obesity (MHO) is a stable benign condition is unclear. The aim of this study was to estimate the transition of MHO subjects to unhealthy obesity (occurrence of cardio-metabolic events and/or risk factors) and its predictors.
methodsWe conducted an explorative follow-up study in a subset of MHO patients > 40 years without any cardio-metabolic risk factors and with normal LDL cholesterol (LDLc) levels, identified among 1530 obese patients. Due to the low sample size, a bootstrap approach was applied to identify the variables to be included in the final multivariate discrete-time logit model.
resultsThe prevalence of MHO was 3.7%. During the follow-up (mean 6.1 years, SD 2.0), none of the MHO reported cardiovascular events, diabetes or prediabetes; 26 subjects developed risk factors (53% high LDLc and 50% hypertension). At the 6 and 12-year of follow-up, the cumulative incidence of transition to unhealthy obesity was 44% (95% CI 31-59%) and 62% (95% CI 45-79%), the incidence of high LDLc was 23% (95% CI 13-37%) and 40% (95% CI 25-59%) and that of hypertension was 20% (95% CI 11-33%) and 30% (95% CI 17-48%). LDLc and duration of follow-up were independent predictors of the transition from MHO to unhealthy obesity [OR 1.038 (1.005-1.072) and 1.360 (1.115-1.659)].
conclusionsResults suggest that (a) MHO individuals do not move over time forward diabetes/prediabetes but develop risk factors, such as hypertension and higher LDL c that worsen the cardiovascular prognosis; (b) LDLc and the flow of time independently predict the transition to unhealthy status. LEVEL OF EVIDENCE: Level III, cohort study.
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