Evidence map›Paper›PMID 30374850›Full record

Observational studyJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?

Daphne L Jonker, Bouke P C Hazenberg, Hans L A Nienhuis, Riemer H J A Slart, Andor W J M Glaudemans, Walter Noordzij

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
  7. Review
  8. Cardiomyopathy and autonomic neuropathy in hereditary amyloidosis: Defining the cart and the horse.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  9. Article
  10. Time for new imaging and therapeutic approaches in cardiac amyloidosis.European journal of nuclear medicine and molecular imaging · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daphne L JonkerDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. d.l.jonker@umcg.nl.
Bouke P C HazenbergDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hans L A NienhuisDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Riemer H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andor W J M GlaudemansDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Walter NoordzijDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNuclear imaging modalities using

methodsAll TTR mutation carriers and ATTRm patients who underwent both

results39 patients (13 carriers and 26 ATTRm patients) were included in this study. Patients with cardiomyopathy, with or without cardiac autonomic neuropathy, had lower late HMR than similar patients without cardiomyopathy [median 1.1 (range 1.0-1.5) and 1.5(1.2-2.6) vs 2.4 (1.4-3.8) and 2.5 (1.5-3.7), respectively, P < 0.001]. Late HMR and wash-out (inversely) correlated with NT-proBNP r = - 0.652 (P < 0.001) and r = 0.756 (P < 0.001), respectively. Furthermore, late HMR and wash-out (inversely) correlated with cardiac

conclusionIn case of heart failure,

Indexed as

3-IodobenzylguanidineAdultAgedAmyloid Neuropathies, FamilialAutonomic Nervous System DiseasesBone and BonesDiphosphonatesFemaleHeartHeart FailureHumansMaleMediastinumMiddle AgedNatriuretic Peptide, BrainOrganotechnetium Compounds3-IodobenzylguanidineDiphosphonatesNatriuretic Peptide, BrainOrganotechnetium CompoundsPeptide FragmentsPrealbuminpro-brain natriuretic peptide (1-76)Radiopharmaceuticalstechnetium 99m hydroxyethylene-diphosphonateTTR protein, humanATTRmautonomic function testsbone scintigraphyCardiac amyloidosiscardiac biomarkersMIBG

Identifiers

PMID30374850
PMCPMC7599160
OpenAlexW2898818822

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.