Evidence map›Paper›PMID 30374847›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic

Marina Piccinelli, Sang-Geon Cho, Ernest V Garcia, Erick Alexanderson, Joo Myung Lee, C David Cooke, Nikhil Goyal, Mauricio Santos Sanchez, Russel D Folks, Zhengjia Chen and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Determination of [N-13]-ammonia extraction fraction in patients with coronary artery disease by calibration to invasive coronary and fractional flow reserve.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  3. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  4. Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  5. Myocardial-coronary fusion imaging with positron emission tomography and computed tomography: Benchmarking and slingshotting.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Marina PiccinelliDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA. mpiccin@emory.edu.
Sang-Geon ChoDepartment of Nuclear Medicine, Chonnam National University, Gwangju, Korea.
Ernest V GarciaDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
Erick AlexandersonNuclear Cardiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico.
Joo Myung LeeHeart Vascular Stroke Institute, Samsung Medical Center, Seoul, Korea.
C David CookeDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
Nikhil GoyalDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
Mauricio Santos SanchezNuclear Cardiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico.
Russel D FolksDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
Zhengjia ChenDepartment of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA.
John VotawDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
Bon-Kwon KooDepartment of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
Hee-Seung BomDepartment of Nuclear Medicine, Chonnam National University, Gwangju, Korea.
Emory University · USChonnam National University · KRInstituto Nacional de Cardiología · MXSamsung Medical Center · KRSeoul National University Hospital · KR

Funding

Quantification of myocardial blood flow using Dynamic PET/CTA fused imagery to determine physiological significance of specific coronary lesionsR01HL143350 · NHLBI · EMORY UNIVERSITY · PI PICCINELLI, MARINA · 2018 to 2021
$2.4M
Myocardial blood flow quantitation with the novel PET F-18 Fluripidaz imaging tracerR44HL123069 · NHLBI · SYNTERMED, INC, · PI MADDAHI, JAMSHID, VAN TRAIN, KENNETH · 2016 to 2017
$999k
NHLBI NIH HHS R01 HL143350NHLBI NIH HHS R44 HL123069
6 · The paper itself

Abstract

objectivesThe goal of the present work is to present a novel methodology for the extraction of MBF, MFR and RFR along coronary arteries by means of multimodality image fusion of dynamic PET and CCTA images.

backgroundFFR is the reference standard to identify flow-limiting lesions, but its invasiveness limits broad application. New noninvasive methodologies are warranted to stratify patients and guide treatment.

methodsA group of 16 low-risk CAD subjects who underwent both

resultsLow-risk ranges for MBF. MFR and RFR for LAD, LCX and rPDA were computed for the entire cohort and separated by gender. Computed low-risk ranges were used to assess a prospective patient with suspected CAD.

conclusionsOur vessel-specific functional indexes and 3D displays offer promise to more closely replicate what is commonly performed during a catheterization session and have the potential of providing effective noninvasive tools for the identification of flow-limiting lesions and image-guided therapy.

Indexed as

Computed Tomography AngiographyPositron-Emission TomographyAgedCoronary Artery DiseaseCoronary CirculationCoronary VesselsFeasibility StudiesFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsRetrospective StudiesCADCTimage-guided applicationmultimodalitymyocardial blood flowPET

Identifiers

PMID30374847
PMCPMC6488439
OpenAlexW2899133131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.