Evidence map›Paper›PMID 30374830›Full record

ReviewClinical oral investigations2019

Administration of systemic antibiotics during non-surgical periodontal therapy-a consensus report.

B Pretzl, S Sälzer, B Ehmke, U Schlagenhauf, B Dannewitz, H Dommisch, P Eickholz, Y Jockel-Schneider

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The impact of prebiotics and probiotics on the oral microbiome of individuals with periodontal disease: a scoping review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

B PretzlDepartment of Conservative Dentistry, Section of Periodontology, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, 69120, Heidelberg, Germany. bernadette.pretzl@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0003-4230-593X
S SälzerClinic for Conservative Dentistry and Periodontology, University Hospital of Schleswig-Holstein, 24105, Kiel, Germany.
B EhmkeDepartment of Periodontology, University Hospital Münster, 48149, Münster, Germany.
U SchlagenhaufDivison of Periodontology, University Hospital of Julius-Maximilians-University, 97070, Würzburg, Germany.
B DannewitzDepartment of Periodontology, Center of Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, 60596, Frankfurt, Germany.
H DommischDepartment of Periodontology and Synoptic Dentistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
P EickholzDepartment of Periodontology, Center of Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt/Main, 60596, Frankfurt, Germany.
Y Jockel-SchneiderDivison of Periodontology, University Hospital of Julius-Maximilians-University, 97070, Würzburg, Germany.

Funding

Commission for Young Scientists and Gender Equality, University of Wuerzburg 2.2-220.522-97/15_1IZKF 2.2-220.522-97/2015_1
6 · The paper itself

Abstract

aimThe aim of this meta-review was to evaluate whether there is a meaningful clinical benefit regarding the use of systemic adjunctive antibiotics in the treatment of patients with periodontitis. Additionally, a consensus regarding possible recommendations for future administration of antibiotics should be reached.

methodsA structured literature search was performed by two independent investigators focusing on systematic reviews (SR) covering adjunctive systemic antibiosis during non-surgical periodontal therapy. Additionally, recent randomized clinical trials (RCT, July 2015 to July 2017) were searched systematically to update the latest SR. Results were summarized and discussed in a plenary to reach a consensus.

resultsMostly, systematic reviews and RCTs showed a significant positive effect of adjunctive systematic antibiosis compared to controls. These positive effects gain clinical relevance in patients with severe periodontal disease aged 55 years and younger.

conclusionSystemic antibiotics as an adjunct to non-surgical periodontal therapy should be sensibly administered and restrictively used. Only certain groups of periodontitis patients show a significant and clinically relevant benefit after intake of systemic antibiosis during periodontal therapy. CLINICAL RELEVANCE: Avoiding antibiotic resistance and possible side effects on the human microbiome should be a focus of dentists and physicians. Thus, a sensible administration of antibiotics is mandatory. This manuscript suggests guidelines for a reasonable use.

Indexed as

Anti-Bacterial AgentsPeriodontitisCombined Modality TherapyDental ScalingHumansMiddle AgedAnti-Bacterial AgentsAdjunctive systemic antibiosisAntibioticNon-surgical therapyPeriodontal therapy

Identifiers

PMID30374830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.