Evidence map›Paper›PMID 30374604›Full record

ArticlePediatric nephrology (Berlin, Germany)2019

Soluble tumor necrosis factor receptors are associated with severity of kidney dysfunction in pediatric chronic kidney disease.

Janaina Matos Moreira, Albená Nunes da Silva, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Arthur Melo Kummer, Ana Cristina Simões E Silva

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Janaina Matos MoreiraInterdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Albená Nunes da SilvaExercise Immunology and Inflammation Laboratory (LABIIEX/CEDUFOP), Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Érica Leandro Marciano VieiraInterdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Antônio Lúcio TeixeiraInterdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Arthur Melo KummerInterdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Ana Cristina Simões E SilvaInterdisciplinary Laboratory of Medical Research (LIIM) of the Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. acssilva@hotmail.com.ORCID 0000-0001-9222-3882
Universidade Federal de Minas Gerais · BRUniversidade Federal de Ouro Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn adult chronic kidney disease (CKD) patients, there is a positive association between inflammation and progressive renal dysfunction. Higher levels of soluble receptors of tumor necrosis factor (sTNFR) have been related to worst prognosis of adult CKD patients. Therefore, the present study aimed to evaluate soluble TNF receptors in children and adolescents with CKD and to search for an association with clinical and laboratory features.

methodsDemographic, clinical, anthropometric, and laboratory data were evaluated in 34 pediatric patients with CKD and in 34 healthy sex- and age-matched controls. Blood samples were collected in both groups to measure sTNFR by enzyme-linked immunosorbent assay. The modified Schwartz formula was used to estimate glomerular filtration rate (GFR).

resultsPediatric patients with CKD had significantly higher plasma concentrations of soluble TNF receptors types 1 and 2 (sTNFR1 and sTNFR2) in comparison to sex- and age-matched healthy controls. Plasma levels of sTNFR1 and sTNFR2 increased progressively as renal function worsened, being inversely and significantly correlated with GFR (r = - 0.853 for sTNFR1 and GFR, r = - 0.729 for sTNFR2 and GFR).

conclusionsChildren and adolescents with CKD exhibited higher plasma levels of sTNFR1 and sTNFR2 than healthy controls, which increased in relation to renal function deterioration. Plasma levels of sTNFR1 and sTNFR2 emerge as markers of progressive CKD in pediatric patients.

Indexed as

Severity of Illness IndexAdolescentBiomarkersChildCross-Sectional StudiesDisease ProgressionFemaleGlomerular Filtration RateHealthy VolunteersHumansKidneyMaleReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRenal Insufficiency, ChronicBiomarkersReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IITNFRSF1A protein, humanTNFRSF1B protein, humanChildrenChronic kidney diseaseCytokinesGlomerular filtration rateInflammationTumor necrosis factor

Identifiers

PMID30374604
OpenAlexW2898966427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.