SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019
Lithium use and risk of fracture: a systematic review and meta-analysis of observational studies.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Drug-Induced Osteoporosis.Journal of clinical medicine · 2026Review
- Bioengineered mPCL scaffolds with LiCl-stimulated hPDLCs cell sheets for enhanced periodontal regeneration.Clinical oral investigations · 2025Article
- Association Between Lithium Use and Periprosthetic Fracture After Total Hip Arthroplasty.Arthroplasty today · 2025Article
- Article
- Hair and Serum Trace Element and Mineral Levels Profiles in Women with Premenopausal and Postmenopausal Osteoporosis.Biological trace element research · 2024Article
- [Lithium treatment for affective disorders in old age].Der Nervenarzt · 2024Review
- Article
- [Lithium treatment for affective disorders in old age].Zeitschrift fur Gerontologie und Geriatrie · 2023Review
- Bipolar Disorder and Bone Mineral Density Z-Scores in Relation to Clinical Characteristics and Lithium Medication.Journal of clinical medicine · 2022Article
- Effect of chronic lithium on mechanical sensitivity and trabecular bone loss induced by type-1 diabetes mellitus in mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Clarification of some issues using Bayesian methods and model selection in meta-analysis and reporting.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The preconditioning of lithium promotes mesenchymal stem cell-based therapy for the degenerated intervertebral disc via upregulating cellular ROS.Stem cell research & therapy · 2021Article
- Lithium in Portuguese Bottled Natural Mineral Waters-Potential for Health Benefits?International journal of environmental research and public health · 2020Article
- Lithium Content of 160 Beverages and Its Impact on Lithium Status inFoods (Basel, Switzerland) · 2020Article
- The Skeletal-Protecting Action and Mechanisms of Action for Mood-Stabilizing Drug Lithium Chloride: Current Evidence and Future Potential Research Areas.Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis summarized the results from nine eligible observational studies. Lithium use was significantly associated with a decrease risk of fractures.
introductionThe association between lithium use and risk of fracture is uncertain. To date, there have been no meta-analyses that have studied the association between the two. We conducted a systematic review and meta-analysis to examine the effect of lithium medication on the risk of fracture.
methodsA comprehensive literature search was performed in PubMed, Embase, and MEDLINE to include eligible observational studies. Three reviewers conducted the literature search, study selection, study appraisal, and data abstraction independently. Random effects models were used to obtain the overall estimate for meta-analysis. Cochran's Q and Higgins' I
resultsOf the 3819 studies that were identified by our search strategy, eight were eligible for the systematic review, while seven of them qualified for the meta-analysis. In studies that reported risk ratio (RR) of fracture as an outcome (five studies [n = 1,134,722]), lithium use was associated with a 20% decrease in risk of fracture (RR = 0.80; 95% CI, 0.73-0.87; p < 0.01). A decreased risk of fracture associated with lithium was also observed in studies that adjusted for previous fractures (RR = 0.81; 95% CI, 0.73-0.89; p < 0.01). The decreased risk of fracture associated with lithium use remained consistent in all the analyses with different inclusion criteria. Neither significant heterogeneity nor significant publication bias was observed.
conclusionThe present systematic review and meta-analysis demonstrated that lithium use was associated with a significant decreased risk of fracture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.