Evidence map›Paper›PMID 30374522›Full record

SynthesisInternational journal of colorectal disease2019

The contribution of endoscopy quality measures to the development of interval colorectal cancers in the screening population: a systematic review.

Deirdre M Nally, Athena Wright Ballester, Gintare Valentelyte, Dara O Kavanagh

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Deirdre M NallyDepartment of Surgical Affairs, 2nd Floor, Royal College of Surgeons of Ireland, 121 St. Stephen's Green, Dublin 2, Ireland. deirdrenally@rcsi.com.ORCID http://orcid.org/0000-0001-8590-0021
Athena Wright BallesterDepartment of Surgical Affairs, 2nd Floor, Royal College of Surgeons of Ireland, 121 St. Stephen's Green, Dublin 2, Ireland.
Gintare ValentelyteDepartment of Health Outcomes Research, Royal College of Surgeons, Beaux Lane House, Mercer Street Lower, Dublin 2, Ireland.
Dara O KavanaghDepartment of Surgical Affairs, 2nd Floor, Royal College of Surgeons of Ireland, 121 St. Stephen's Green, Dublin 2, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColon cancer is the second most common cause of cancer-related death and an important cause of morbidity. The natural history of carcinogenesis, via the adenoma-carcinoma sequence, permits screening, which reduces the relative risk of mortality by up to 16%. The efficacy of a screening programme is limited by the growth of interval colorectal cancers between screening examinations. Quantifying the rate of interval cancers and delineating contributing endoscopic factors are crucial to maximise the benefit of a screening program.

methodsA systematic review was performed in accordance with PRISMA principles. Electronic databases were interrogated with a considered search strategy, and reference lists of retrieved papers were surveyed. For inclusion, studies included the rate of interval cancer (stated or calculated) and reported at least one of a predefined list of endoscopy characteristics. The primary outcome was to establish the rate of interval cancers. The secondary outcome was to determine the association between endoscopy quality measures and interval cancers.

resultsThe search yielded 2067 papers. Seventy-six full text papers were reviewed. Fifteen papers met the inclusion criteria. In total, there were 117,793 colon cancers, 7281 of which were interval lesions, giving an overall rate of 6.2%. The adenoma detection rate (ADR) of the endoscopist performing the index operation was the most consistent endoscopy factor associated with development of interval cancers. The impact of setting, volume and bowel preparation varied between papers.

conclusionInterval cancers reduce the efficacy of colorectal screening programmes. Ensuring the quality of the endoscopy process, specifically by increasing the ADR of practitioners, is crucial to the reduction of the rate of interval cancers.

Indexed as

AgedCecumColonoscopyColorectal NeoplasmsEarly Detection of CancerFemaleHumansIntubationMaleTreatment OutcomeColorectal cancerInterval cancerPost-colonoscopy cancerScreening

Identifiers

PMID30374522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.