ArticleNorthern clinics of Istanbul2018
The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients.
Article in Northern clinics of Istanbul, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- The Neutrophil-to-Lymphocyte Ratio in Fibromyalgia: A Systematic Review with a Neuroimmune Perspective.Brain sciences · 2026Review
- Hyperbaric Oxygen Therapy as a Therapeutic Option for Patients with Fibromyalgia.Current rheumatology reviews · 2026Review
- Serum choline, leptin and interleukin-6 levels in fibromyalgia syndrome-induced pain: a case-control study.BMC musculoskeletal disorders · 2025Article
- Relationship between pain, functionality, and body composition in patients with fibromyalgia: cross-sectional study.Frontiers in medicine · 2025Article
- Diet and Lifestyle Modifications for Fibromyalgia.Current rheumatology reviews · 2024Review
- Altered response to Toll-like receptor 4 activation in fibromyalgia: A low-dose, human experimental endotoxemia pilot study.Brain, behavior, & immunity - health · 2023Article
- Elevated high sensitive C-reactive protein in fibromyalgia.Frontiers in psychiatry · 2023Article
- The relationship between serum leptin, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 levels and clinical parameters in primary fibromyalgia patients.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain.Clinical epigenetics · 2022Article
- Elevated highly sensitive C-reactive protein in fibromyalgia associates with symptom severity.Rheumatology advances in practice · 2022Article
- Serum leptin, a potential predictor of long-term angiographic progression in Takayasu's arteritis.International journal of rheumatic diseases · 2019Article
- Role of inflammation in the pathogenesis and treatment of fibromyalgia.Rheumatology international · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate whether there is a correlation between serum leptin level, disease activity and inflammation markers in patients with fibromyalgia syndrome (FMS).
methodsA total of 48 patients with FMS diagnosed according to the 1990 American College of Rheumatology criteria were included in the study, as well as 36 healthy women as controls. The Visual Analogue Scale was used to gauge pain severity, the Fibromyalgia Impact Questionnaire was used to assess physical function, the 36-Item Short Form Health Survey was used to examine quality of life, and depression was measured with the Beck Depression Inventory. Blood samples were examined for erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), high-sensitivity CRP level (hsCRP), the neutrophil-to-lymphocyte ratio (NLR), and the serum leptin level was determined using the enzyme-linked immunosorbent assay method.
resultsThe serum leptin level in patients with FMS was significantly higher than in the healthy group. However, no significant relationship was found between leptin level and clinical and inflammatory parameters. In addition, there were no significant differences between the patients and the control group in measurements of ESR, CRP, hsCRP, or NLR.
conclusionA higher serum leptin level in patients with FMS suggested that leptin may play role in the pathogenesis of FMS, yet there was no relationship between leptin and clinical and inflammatory parameters, suggesting that leptin is not an indicator of disease activity in FMS. Additional research should be performed with larger patient groups.
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