ArticleCommunications biology2018
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles.
Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 248 citations in OpenAlex.
- Advancing intradermal vaccine delivery: Focus on hollow microneedles and skin models.Human vaccines & immunotherapeutics · 2026Review
- Vitiligo-like depigmentation as an accessible readout of antitumour immunity in melanoma immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation.Biosensors · 2026Review
- Microneedle-based platforms for wound healing: recent advances.Journal of materials chemistry. B · 2026Review
- Xylem-inspired anisotropic porous silk microneedles enable efficient interstitial fluid sampling for local biomarker and proteomic profiling of skin diseases.Materials today. Bio · 2026Article
- Vacuum-Assisted Microneedle Platforms for Dermal Interstitial Fluid Sampling.Pharmaceutics · 2026Review
- Interstitial fluid N-glycans serve as a proxy for serum biomarker discovery in a pilot study.Scientific reports · 2026Article
- Microneedle-based theranostics for melanoma: Advances and outlook.Materials today. Bio · 2026Review
- Continuous monitoring of blood-interstitial fluid intercompartmental molecular kinetics in freely moving animals.Science advances · 2026Article
- Biosensor-Integrated Microneedle Devices for Diagnosis and Treatment of Chronic and Infectious Diseases: Current Status, Trends and Challenges.Biosensors · 2026Review
- Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges.Advanced healthcare materials · 2026Review
- MiRNAs in Interstitial Skin Fluid Sampled with Swellable Hydrogel Microneedles Are Locally Deregulated Near Malignant Skin Lesions in Early Stages of Cutaneous Squamous Cell Carcinoma.ACS biomaterials science & engineering · 2026Article
- Deconvolution Methods to Link Multi-Omics Data to Cell Type-Specific Extracellular Vesicle Abundances.Proteomics · 2026Review
- Dual-responsive zwitterionic hydrogel microneedle patch for the on-site detection of two alzheimer's disease - related miRNAs.Journal of nanobiotechnology · 2026Article
- Investigation of Vibration-Induced Transport of Newtonian and Non-Newtonian Fluids in Porous Media Using Lattice Boltzmann Method.Bioengineering (Basel, Switzerland) · 2025Article
- Enhanced extraction of human interstitial fluid using microneedles and laser-induced fluid recruitment.iScience · 2025Article
- Electrochemical and Nanomaterial-Based Strategies for Nonenzymatic Glucose Detection: A Review.ChemistryOpen · 2025Review
- Immunization with VLP-based vaccines induces high IgG antibody titers in dermal interstitial fluid.NPJ vaccines · 2025Article
- A microneedle device for rapid dermal interstitial fluid sampling.Science advances · 2025Article
- The Future of Tumor Markers: Advancing Early Malignancy Detection Through Omics Technologies, Continuous Monitoring, and Personalized Reference Intervals.Biomolecules · 2025Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Dermal interstitial fluid (ISF) is an underutilized information-rich biofluid potentially useful in health status monitoring applications whose contents remain challenging to characterize. Here, we present a facile microneedle approach for dermal ISF extraction with minimal pain and no blistering for human subjects and rats. Extracted ISF volumes were sufficient for determining transcriptome, and proteome signatures. We noted similar profiles in ISF, serum, and plasma samples, suggesting that ISF can be a proxy for direct blood sampling. Dynamic changes in RNA-seq were recorded in ISF from induced hypoxia conditions. Finally, we report the first isolation and characterization, to our knowledge, of exosomes from dermal ISF. The ISF exosome concentration is 12-13 times more enriched when compared to plasma and serum and represents a previously unexplored biofluid for exosome isolation. This minimally invasive extraction approach can enable mechanistic studies of ISF and demonstrates the potential of ISF for real-time health monitoring applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.