ArticleEuropean thyroid journal2018
Levothyroxine/Liothyronine Combination Therapy and Quality of Life: Is It All about Weight Loss?
Article in European thyroid journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial.BMC endocrine disorders · 2025Trial
- Long-term outcomes of LT4/LT3 combination treatment for persistent hypothyroid symptoms.European thyroid journal · 2025Article
- Primary hypothyroidism and quality of life.Nature reviews. Endocrinology · 2022Review
- Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022Article
- Evaluating health outcomes in the treatment of hypothyroidism.Frontiers in endocrinology · 2022Review
- Relatively Lower FT3 Levels Are Associated with Impaired Quality of Life in Levothyroxine-Treated Patients with Hashimoto Thyroiditis.International journal of endocrinology · 2022Article
- T4+T3 Combination Therapy: An Unsolved Problem of Increasing Magnitude and Complexity.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism.Endocrine · 2021Article
- What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review.Journal of clinical medicine · 2021Review
- Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.European thyroid journal · 2021Article
- Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control Study.Journal of clinical medicine · 2020Article
- Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review.Endocrine connections · 2020Review
- T4 + T3 combination therapy: any progress?Endocrine · 2019Review
- Assessment of the Adequacy of Thyroid Hormone Replacement Therapy in Hypothyroidism.Frontiers in endocrinology · 2019Article
- Functional and Symptomatic Individuality in the Response to Levothyroxine Treatment.Frontiers in endocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAccording to one hypothesis, the popularity of levothyroxine (L-T
methodsIn an open-label cohort study, all hypothyroid patients referred to the University Hospital endocrine clinic due to persistent symptoms despite adequate L-T
resultsTwenty-three patients participated (91% women, median age 47 years). The ThyPRO-39 composite score decreased from a median of 54 (quartiles: 34, 74) to 15 (11, 28) after 3 months (
conclusionOur study on hypothyroid patients switched from L-T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.