Evidence map›Paper›PMID 30374425›Full record

ArticleEuropean thyroid journal2018

2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism.

Luca Persani, Georg Brabant, Mehul Dattani, Marco Bonomi, Ulla Feldt-Rasmussen, Eric Fliers, Annette Gruters, Dominique Maiter, Nadia Schoenmakers, A S Paul van Trotsenburg

Open access · bronzeAbstract read
In one paragraph

Article in European thyroid journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 207 citations in OpenAlex.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 6 countries.

Luca PersaniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Georg BrabantExperimental and Clinical Endocrinology Medical Clinic I - University of Lübeck, Lübeck, Germany.
Mehul DattaniGenetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London, United Kingdom.
Marco BonomiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Ulla Feldt-RasmussenDepartment of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Eric FliersDepartment of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Annette GrutersDepartment for Pediatric Endocrinology and Diabetes, Charité University Medicine, Berlin, Germany.
Dominique MaiterDepartment of Endocrinology and Nutrition, UCL Cliniques Saint-Luc, Brussels, Belgium.
Nadia SchoenmakersUniversity of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
A S Paul van TrotsenburgDepartment of Pediatric Endocrinology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
IRCCS Istituto Auxologico Italiano · ITAddenbrooke's Hospital · GBCliniques Universitaires Saint-Luc · BECopenhagen University Hospital · DKEmma Kinderziekenhuis · NLUniversity College London · GBUniversity Hospital Heidelberg · DEUniversity of Amsterdam · NLUniversity of Lübeck · DE

Funding

Medical Research Council MC_UU_12012/5
6 · The paper itself

Abstract

objectivesCentral hypothyroidism (CeH) is a rare form of hypothyroidism characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due to its origin and the whole clinical context, CeH represents a challenging condition in clinical practice as it is characterized by suboptimal accuracy of clinical and biochemical parameters for diagnosis and management. Since no expert consensus or guidance for this condition is currently available, a task force of experts received the commitment from the European Thyroid Association (ETA) to prepare this document based on the principles of clinical evidence. STUDY

designThe task force started to work in February 2017 and after a careful selection of appropriate references (cohort studies, case reports, expert opinions), a preliminary presentation and live discussion during the 2017 ETA meeting, and several revision rounds, has prepared a list of recommendations to support the diagnosis and management of patients with CeH.

resultsDue to the particular challenges of this rare condition in the different ages, the target users of this guidance are pediatric and adult endocrinologists. Experts agreed on the need to recognize and treat overt CeH at all ages, whereas treatment of milder forms may be dispensable in the elderly (> 75 years).

conclusionsDespite the lack of randomized controlled clinical trials, the experts provide 34 recommendations supported by variable levels of strength that should improve the quality of life of the affected patients and reduce the metabolic and hormonal consequences of inadequate management.

Indexed as

Central hypothyroidismGuidelinesHormone replacement therapyPituitarySubclinical hypothyroidismThyroidThyrotropinThyroxineTRH

Identifiers

PMID30374425
PMCPMC6198777
OpenAlexW2883658667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.