Evidence map›Paper›PMID 30374416›Full record

ArticleBone research2018

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration.

Ke Zhang, Suping Wang, Chenchen Zhou, Lei Cheng, Xianling Gao, Xianju Xie, Jirun Sun, Haohao Wang, Michael D Weir, Mark A Reynolds and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 305 citations in OpenAlex.

  1. Review
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  11. Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  16. Article
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ke Zhang *1Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Suping Wang *2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Chenchen Zhou *3State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Deptartment of Cariology and Endodonics West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Lei Cheng2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Xianling Gao2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Xianju Xie1Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Jirun Sun5Volpe Research Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, MD USA.
Haohao Wang2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Michael D Weir2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Mark A Reynolds2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
Ning Zhang1Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Yuxing Bai1Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Hockin H K Xu2Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD USA.
University of Maryland, Baltimore · USCapital Medical University · CNNational Institute of Standards and Technology · USSichuan University · CN

Funding

Novel Dental Resin Composites with Improved Service LifeU01DE023752 · NIDCR · AMERICAN DENTAL ASSOCIATION FOUNDATION · PI SUN, JIRUN · 2013 to 2017
$2.2M
Development of high performance, caries-inhibiting dental nano-materialsR01DE017974 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI XU, HUAKUN · 2008 to 2011
$1.0M
NIDCR NIH HHS R01 DE017974NIDCR NIH HHS U01 DE023752
6 · The paper itself

Abstract

Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals. Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material's responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.

Identifiers

PMID30374416
PMCPMC6196224
OpenAlexW2897868538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.