Evidence map›Paper›PMID 30374290›Full record

ArticleFrontiers in molecular neuroscience2018

Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs.

Joris Comhair, Jens Devoght, Giovanni Morelli, Robert J Harvey, Victor Briz, Sarah C Borrie, Claudia Bagni, Jean-Michel Rigo, Serge N Schiffmann, David Gall and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  7. Journal of clinical medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Joris ComhairLaboratory of Neurophysiology, ULB-Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
Jens DevoghtBIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
Giovanni MorelliBIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
Robert J HarveySchool of Health and Sport Sciences, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
Victor BrizCenter for Human Genetics and Leuven Research Institute for Neuroscience and Disease, KU Leuven, Leuven, Belgium.
Sarah C BorrieCenter for Human Genetics and Leuven Research Institute for Neuroscience and Disease, KU Leuven, Leuven, Belgium.
Claudia BagniCenter for Human Genetics and Leuven Research Institute for Neuroscience and Disease, KU Leuven, Leuven, Belgium.
Jean-Michel RigoBIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
Serge N SchiffmannLaboratory of Neurophysiology, ULB-Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
David GallLaboratory of Neurophysiology, ULB-Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
Bert BrôneBIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
Svetlana M MolchanovaLaboratory of Neurophysiology, ULB-Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
Hasselt University · BEUniversité Libre de Bruxelles · BEVIB-KU Leuven Center for Cancer Biology · BEUniversity of the Sunshine Coast · AUVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

Medical Research Council G0500833Medical Research Council MR/J004049/1Medical Research Council MR/M013502/1
6 · The paper itself

Abstract

Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in

Indexed as

autism spectrum disordersdorsal striatumglycine receptorsmedium spiny neuronsspontaneous activitysynaptic development

Identifiers

PMID30374290
PMCPMC6196267
OpenAlexW2897241360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.