ArticleNature communications2018
Line excitation array detection fluorescence microscopy at 0.8 million frames per second.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
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- Multicolor iLIFE (m-iLIFE) volume cytometry for high-throughput imaging of multiple organelles.Scientific reports · 2024Article
- Numerical study of a convective cooling strategy for increasing safe power levels in two-photon brain imaging.Biomedical optics express · 2024Article
- High-throughput light sheet imaging of adult and larvalRSC advances · 2024Article
- Dynamic Volumetric Imaging of Mouse Cerebral Blood Vessels In Vivo with an Ultralong Anti-Diffracting Beam.Molecules (Basel, Switzerland) · 2023Article
- Wavefront engineered light needle microscopy for axially resolved rapid volumetric imaging.Biomedical optics express · 2022Article
- High-speed label-free confocal microscopy ofBiomedical optics express · 2021Article
- A polymer index-matched to water enables diverse applications in fluorescence microscopy.Lab on a chip · 2021Article
- Planar Laser Activated Neuronal Scanning (PLANS) System forFrontiers in optics. Annual Meeting of the Optical Society of America · 2020Article
- Parallel array with axially coded light-sheet microscope.Light, science & applications · 2020Article
- Digging deeper: methodologies for high-content phenotyping in Caenorhabditis elegans.Lab animal · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Three-dimensional, fluorescence imaging methods with ~1 MHz frame rates are needed for high-speed, blur-free flow cytometry and capturing volumetric neuronal activity. The frame rates of current imaging methods are limited to kHz by the photon budget, slow camera readout, and/or slow laser beam scanners. Here, we present line excitation array detection (LEAD) fluorescence microscopy, a high-speed imaging method capable of providing 0.8 million frames per second. The method performs 0.8 MHz line-scanning of an excitation laser beam using a chirped signal-driven longitudinal acousto-optic deflector to create a virtual light-sheet, and images the field-of-view with a linear photomultiplier tube array to generate a 66 × 14 pixel frame each scan cycle. We implement LEAD microscopy as a blur-free flow cytometer for Caenorhabditis elegans moving at 1 m s
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.