ArticleScientific reports2018
Distinct phenotypic traits of Staphylococcus aureus are associated with persistent, contagious bovine intramammary infections.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Mastitis-Associated Bacterial Isolates and Antimicrobial Resistance in a Single Dairy Herd in the Akmola Region, Kazakhstan.Antibiotics (Basel, Switzerland) · 2026Article
- Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-AssociatedMicroorganisms · 2026Article
- Virulence of Bacteria Causing Mastitis in Dairy Cows: A Literature Review.Microorganisms · 2025Review
- EAVLD 2024 - 7Italian journal of food safety · 2024Article
- Effects of pathogen-specific clinical mastitis occurrence in the first 100 days of lactation 1 on future mastitis occurrence in Holstein dairy cows: An observational study.JDS communications · 2023Article
- Prevalence of the SigB-Deficient Phenotype among ClinicalAntibiotics (Basel, Switzerland) · 2023Article
- Article
- The Role of Biofilms in the Pathogenesis of Animal Bacterial Infections.Microorganisms · 2023Review
- A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the Innate Immunity Response in Bovine Mammary Epithelial Cells.Biomedicines · 2022Article
- Review
- Comparative secretome analysis ofVirulence · 2022Article
- Usefulness of molecular typing methods for epidemiological and evolutionary studies ofSaudi journal of biological sciences · 2022Review
- Terpenes Combinations Inhibit Biofilm Formation inMicroorganisms · 2022Article
- Persistence of Staphylococcus spp. in milk from cows undergoing homeopathy to control subclinical mastitis.BMC veterinary research · 2022Article
- Prevalence, Antimicrobial Resistance, and Characterization ofAnimals : an open access journal from MDPI · 2022Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives.BMC veterinary research · 2022Review
- Distinguishing the milk microbiota of healthy goats and goats diagnosed with subclinical mastitis, clinical mastitis, and gangrenous mastitis.Frontiers in microbiology · 2022Article
- Growth conditions affect biofilms ofCurrent research in microbial sciences · 2021Article
- Bovine milk somatic cell transcriptomic response to Staphylococcus aureus is dependent on strain genotype.BMC genomics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus causing persistent, recurrent bovine intramammary infections are still a major challenge to dairy farming. Generally, one or a few clonal lineages are predominant in dairy herds, indicating animal-to-animal transfers and the existence of distinct pathotypic traits. The aim of this study was to determine if long term persistence and spreading of S. aureus are associated with specific phenotypic traits, including cellular invasion, cytotoxicity and biofilm formation. Mastitis isolates were collected over a 3-years period from a single dairy herd, resulting in two persistent subtypes, the high within-herd prevalent subtype ST9 (CC9)-methicillin-susceptible S. aureus (MSSA), designated HP/ST9, and the low within-herd prevalent subtype ST504 (CC705)-MSSA, designated LP/ST504. Characterization of the two different coexisting persistent subtypes showed that the following phenotypic traits are particularly associated with high within-herd prevalence: lack of capsular polysaccharide expression, high cellular invasiveness, low cytotoxicity and high biofilm/ poly-N-acetylglucosamine (PNAG) production, which may concomitantly contribute to the spreading of HP/ST9 within the herd. By contrast to HP/ST9, LP/ST504 is characterized by the formation of colony dendrites, which may help the bacteria to access deeper tissues as niches for persistence in single animals. Thus, within a single herd, two different types of persistence can be found in parallel, allowing longtime persistence of S. aureus in dairy cattle. Furthermore, this study indicates that ST9 (CC9)-MSSA strains, which are currently thought to have their primary reservoir in swine and humans, can also successfully spread to new hosts and persist in dairy herds for years.
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