Evidence map›Paper›PMID 30374130›Full record

ArticleNature immunology2018

Activated β-catenin in Foxp3

Tomokazu Sumida, Matthew R Lincoln, Chinonso M Ukeje, Donald M Rodriguez, Hiroshi Akazawa, Tetsuo Noda, Atsuhiko T Naito, Issei Komuro, Margarita Dominguez-Villar, David A Hafler

Erratum issuedAbstract read
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. T-betThe FEBS journal · 2026
    Article
  5. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Cholesterol promotesLife science alliance · 2024
    Article
  18. An autoimmune transcriptional circuit drives FOXP3Science translational medicine · 2024
    Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Tomokazu SumidaDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA. tomokazu.sumida@yale.edu.ORCID http://orcid.org/0000-0002-9806-2642
Matthew R LincolnDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Chinonso M UkejeDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Donald M RodriguezDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Hiroshi AkazawaDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Tetsuo NodaDepartment of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Atsuhiko T NaitoDepartment of Pharmacology, Faculty of Medicine, Toho University School of Medicine, Tokyo, Japan.
Issei KomuroDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Margarita Dominguez-VillarDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
David A HaflerDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Yale University · USThe University of Tokyo · JPJapanese Foundation For Cancer Research · JPToho University · JPTokyo University of Agriculture · JP

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
Yale SPORE in Skin CancerP50CA121974 · NCI · YALE UNIVERSITY · PI DAVID F STERN · 2006 to 2026
$43.9M
TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
Regulatory T Cells in Autoimmune DiseaseU19AI070352 · NIAID · YALE UNIVERSITY · PI HAFLER, DAVID A. · 2006 to 2011
$5.9M
Treatment of Autoimmune Disease by Costimulatory Signal*U19AI046130 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHOURY, SAMIA J. · 1999 to 2007
$5.6M
NCI NIH HHS P50 CA121974NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI045757NIAID NIH HHS U19 AI046130NIAID NIH HHS U19 AI070352
6 · The paper itself

Abstract

Foxp3

Indexed as

AnimalsAutoimmunitybeta CateninGene Expression RegulationHumansInflammationInterferon-gammaInterleukin-10Mice, Inbred C57BLMultiple Sclerosis, Relapsing-RemittingReceptors, Prostaglandin E, EP2 SubtypeT-Lymphocytes, Regulatorybeta CateninCTNNB1 protein, humanCTNNB1 protein, mouseInterferon-gammaInterleukin-10Receptors, Prostaglandin E, EP2 Subtype

Identifiers

PMID30374130
PMCPMC6240373
OpenAlexW2896226908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.