Evidence map›Paper›PMID 30374128›Full record

ArticleNature immunology2018

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Benjamin Knier, Michael Hiltensperger, Christopher Sie, Lilian Aly, Gildas Lepennetier, Thomas Engleitner, Garima Garg, Andreas Muschaweckh, Meike Mitsdörffer, Uwe Koedel and 7 more

Abstract read
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 125 citations in OpenAlex.

  1. Trial
  2. Article
  3. CD13 identifies S100A4Biology direct · 2026
    Article
  4. Myeloid-Derived Suppressor Cells in Inflammatory Arthritis.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Microglial dectin-1/Frontiers in immunology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Integrative genomics and functional immunology reveal Clostridia species as modulators of neuroinflammation in amyotrophic lateral sclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Benjamin KnierDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4187-9472
Michael HiltenspergerDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4600-1394
Christopher SieDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8066-7539
Lilian AlyDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-7051-124X
Gildas LepennetierDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-1899-3149
Thomas EngleitnerInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
Garima GargDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Andreas MuschaweckhDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Meike MitsdörfferDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Uwe KoedelDepartment of Neurology, Klinikum Grosshadern, Ludwig Maximilians University Munich, Munich, Germany.
Bastian HöchstInstitute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany.
Percy KnolleInstitute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-2983-0414
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-5534-6055
Bernhard HemmerDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Roland RadInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
Doron MerklerDepartment of Pathology and Immunology, Division of Clinical Pathology, University of Geneva, Geneva, Switzerland.
Thomas KornDepartment of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. thomas.korn@tum.de.ORCID http://orcid.org/0000-0002-3633-0955
TUM Klinikum · DETechnical University of Munich · DELudwig-Maximilians-Universität München · DEUniversity of Duisburg-Essen · DEUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G

Indexed as

AdolescentAdultAnimalsAutoimmunityB-LymphocytesCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansMaleMiceMiddle AgedMultiple SclerosisMyeloid-Derived Suppressor CellsYoung Adult

Identifiers

PMID30374128
PMCPMC6241855
OpenAlexW2896223525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.