ArticleNature genetics2018
Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
Erratum issuedAbstract readLetter
In one paragraph
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 112 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Subcutaneous panniculitis-like T-cell lymphoma associated with hemophagocytic lymphohistiocytosis: a systematic review of 63 patients reported in the literature.Clinical and experimental medicine · 2023Pooled it
- GermlineHaematologica · 2023Pooled it
- A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Pooled it
- Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.The Journal of allergy and clinical immunology · 2021Trial
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Prognostic Value of Skin Lesion Characteristics in Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Retrospective Cohort Study Assessing the Applicability of T Category of the TNM Classification for Primary Cutaneous Lymphomas Other Than Mycosis Fungoides and Sézary Syndrome.International journal of dermatology · 2026Article
- HAVCR2 in subcutaneous panniculitis-like T cell lymphoma: comment on the article by Chambers et al.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Reply.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Regulation of immune checkpoint molecules in cancer immune evasion and therapy.Nature reviews. Cancer · 2026Review
- Decoding variants of uncertain significance in systemic autoinflammatory diseases.Nature reviews. Rheumatology · 2026Review
- Cutaneous Hematologic Neoplasms in Children: Overview and Update.Dermatopathology (Basel, Switzerland) · 2026Review
- Immune landscape characterization of neurofibromas with atypical features in Neurofibromatosis1 reveals PD-1 and the Tim-3/Galectin-9 pathway as potential therapeutic targets.Acta neuropathologica communications · 2026Article
- Severe Adult HLH/MAS With SPTCL-Like Panniculitis: A Phenotype-Guided, Resource-Adapted Therapeutic Strategy Without Cytotoxic Therapy.Clinical case reports · 2026Article
- Monogenic disorders of immunity: Common variants are not so rare.Cell genomics · 2026Review
- The role of the TIM-3 receptor in inflammatory bowel disease and autoimmunity: implications for TIM-3 and TCR crosstalk.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Clinicopathological Features and Survival Prognosis of Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Population-Based Study from the SEER Database with Supplementary Single-Center Case Validation.International journal of general medicine · 2026Article
- Case Report: Reconciling genomic ambiguity with clinical certainty in refractory panniculitis.Frontiers in immunology · 2026Article
- Unusual Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma.Clinical case reports · 2025Article
- Subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome with significant response to pralatrexate: A case report.JAAD case reports · 2025Article
- Whole Exome Sequencing for the Identification of Mutations in Bone Marrow CD34+Cells in Hodgkin Lymphoma.Current issues in molecular biology · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
44 authors at 16 institutions in 5 countries.
Tenzin Gayden *Department of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-0138-8038
Fernando E Sepulveda *Laboratory of Normal and Pathological Homeostasis of the Immune System, INSERM U1163, Institut Imagine, and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0001-5865-4929
Dong-Anh Khuong-Quang *Children's Cancer Center, The Royal Children's Hospital and Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-6305-7790
Jonathan Pratt *Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Elvis T ValeraDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-4434-429X
Alexandrine GarrigueLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM U1163, Institut Imagine, and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
Susan KelsoLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Frank SicheriLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Leonie G MikaelDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Nancy HamelCancer Research Program, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.
Andrea BajicDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-7177-5757
Rola DaliCanadian Centre for Computational Genomics, Montreal, Quebec, Canada.
Shriya DeshmukhDepartment of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
Dzana DervovicLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Daniel SchramekLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Frédéric GuerinLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM U1163, Institut Imagine, and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
Mikko TaipaleDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Hamid NikbakhtDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-0209-5667
Jacek MajewskiDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3572-9558
Despina MoshousDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID http://orcid.org/0000-0001-6719-3693
Janie CharleboisDivision of Hematology and Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Sharon AbishDivision of Hematology and Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Christine Bole-FeysotPlateforme de Génomique, Institut Imagine, Paris, France.
Patrick NitschkePlateforme de Bioinformatique, Université Paris Descartes, Université Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-2094-3298
Brigitte Bader-MeunierDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
David MitchellDivision of Hematology and Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Catherine ThieblemontHematology and Oncology Unit, Saint Louis Hospital, Paris, France.
Maxime BattistellaParis Diderot University, Université Sorbonne Paris Cité, Paris, France.
Simon GravelMcGill University and Genome Quebec Innovation Center, Montreal, Quebec, Canada.
Van-Hung NguyenDepartment of Pathology, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Rachel ConyersChildren's Cancer Center, The Royal Children's Hospital and Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Jean-Sebastien DianaDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Chris McCormackDepartment of Surgical Oncology, Peter MacCallum Cancer Institute, University of Melbourne, Melbourne, Victoria, Australia.
H Miles PrinceEpworth Healthcare, Melbourne, Victoria, Australia.
Marianne BesnardDepartment of Neonatology, Centre Hospitalier de Polynésie Française, Papeete, French Polynesia.
Stephane BlancheDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Paul G EkertChildren's Cancer Center, The Royal Children's Hospital and Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-2976-8617
Sylvie FraitagDepartment of Anatomy and Cytology/Pathology, Centre Hospitalier Universitaire Paris, Hôpital Necker-Enfants Malades, Paris, France.
William D FoulkesDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-7427-4651
Alain FischerDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Bénédicte NevenDepartment of Pediatric Immunology and Hematology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
David MichonneauParis Diderot University, Université Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0003-4553-3065
Geneviève de Saint BasileLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM U1163, Institut Imagine, and Université Paris Descartes-Sorbonne Paris Cité, Paris, France. genevieve.de-saint-basile@inserm.fr.ORCID http://orcid.org/0000-0002-1913-5269
Nada JabadoDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada. nada.jabado@mcgill.ca.ORCID http://orcid.org/0000-0003-2485-3692
Délégation Paris 5 · FRHôpital Necker-Enfants Malades · FRMcGill University · CAMontreal Children's Hospital · CAUniversity of Toronto · CADélégation Paris 7 · FRMcGill University Health Centre · CARoyal Children's Hospital · AUMcGill University and Génome Québec Innovation Centre · CAOntario Genomics · CAEpworth Hospital · AUInstitut des Maladies Génétiques Imagine · FRLunenfeld-Tanenbaum Research Institute · CAThe University of Melbourne · AUUniversidade de São Paulo · BRUniversity of French Polynesia · PF
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune activation that adversely affects survival
Indexed as
Germ-Line MutationAdolescentAdultAgedAged, 80 and overChildDiagnosis, DifferentialExome SequencingFemaleGenetic Predisposition to DiseaseHepatitis A Virus Cellular Receptor 2HumansInfantLymphohistiocytosis, HemophagocyticLymphoma, T-CellMaleHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.