ArticleNature communications2018
Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease.World journal of gastroenterology · 2025Review
- A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy.Chemical science · 2024Article
- Biomimetic Chiral Nanomaterials with Selective Catalysis Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Mitochondrial metabolism and targeted treatment strategies in ischemic-induced acute kidney injury.Cell death discovery · 2024Review
- Considering the impact of the chirality of therapeutic nanoparticles on cancer therapy.Nanomedicine (London, England) · 2024Article
- Pannexin 1 targets mitophagy to mediate renal ischemia/reperfusion injury.Communications biology · 2023Article
- Gold-Nanoparticle-Based Chiral Plasmonic Nanostructures and Their Biomedical Applications.Biosensors · 2022Review
- Biomimetic Self-Assembled Chiral Inorganic Nanomaterials: A New Strategy for Solving Medical Problems.Biomimetics (Basel, Switzerland) · 2022Review
- Effects of polymer carriers on the occurrence and development of autophagy in drug delivery.Nanoscale advances · 2022Review
- Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants.Antioxidants (Basel, Switzerland) · 2022Review
- Chirality at nanoscale for bioscience.Chemical science · 2022Review
- l-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration.Bioactive materials · 2021Article
- Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation.Journal of nanobiotechnology · 2021Review
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Shining light on chiral inorganic nanomaterials for biological issues.Theranostics · 2021Review
- Engineering of chiral nanomaterials for biomimetic catalysis.Chemical science · 2020Review
- Amplification of enantiomeric excess by dynamic inversion of enantiomers in deracemization of AuNature communications · 2020Article
- Chirality-Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles.Angewandte Chemie (International ed. in English) · 2020Article
- Interplay of intestinal microbiota and mucosal immunity in inflammatory bowel disease: a relationship of frenemies.Therapeutic advances in gastroenterology · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The interactions between chiral nanomaterials and organisms are still challenging and mysterious. Here, a chiral nanodevice made of yolk-shell nanoparticles tetrahedron (UYTe), centralized with upconversion nanoparticles (UCNPs), was fabricated to induce autophagy in vivo. The proposed chiral nanodevice displayed a tunable circular dichroism (CD) signal when modified with different enantiomers of glutathione (GSH). Notably, UYTe showed significant chirality-dependent autophagy-inducing ability after D-GSH-modification because the enhanced oxidative stress and accumulation in living cell. The activation of autophagy resulted in the reduced intracellular CD intensity from the disassembly of the structure. The intracellular ATP concentration was simultaneously enhanced in response to autophagy activity, which was quantitatively bio-imaged with the upconversion luminescence (UCL) signal of the UCNP that escaped from UYTe. The autophagy effect induced in vivo by the chiral UYTe was also visualized with UCL imaging, demonstrating the great potential utility of the chiral nanostructure for cellular biological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.