ArticleNature chemistry2019
From alkylarenes to anilines via site-directed carbon-carbon amination.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 130 citations in OpenAlex.
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- Electrochemically promoted defluorinative sulfoximination and fluorosulfonylation of non-activated aryl fluorides at room temperature.Chemical science · 2025Article
- Selective nitrogen insertion into aryl alkanes.Nature communications · 2024Article
- Synthesis of meta-carbonyl phenols and anilines.Nature communications · 2024Article
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- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- Metal-free visible light mediated direct C-H amination of benzoxazole with secondary amines.Molecular diversity · 2024Article
- Nitrenium ions as new versatile reagents for electrophilic amination.Chemical science · 2023Article
- Towards bioresource-based aggregation-induced emission luminogens from lignin β-O-4 motifs as renewable resources.Nature communications · 2023Article
- Aminodealkenylation: Ozonolysis and copper catalysis convert C(spScience (New York, N.Y.) · 2023Article
- Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling.Nature communications · 2023Article
- Mn(I)-catalyzed sigmatropic rearrangement of β, γ-unsaturated alcohols.Nature communications · 2023Article
- Selective desaturation of amides: a direct approach to enamides.Chemical science · 2022Article
- Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction.Nature communications · 2022Article
- Site-selective amination and/or nitrilationChemical science · 2022Article
- Catalytic Activation of Unstrained C(Aryl)-C(Alkyl) Bonds in 2,2'-Methylenediphenols.Journal of the American Chemical Society · 2022Article
- Modular Two-Step Access to π-Extended Naphthyridine Systems-Potent Building Blocks for Organic Electronics.Angewandte Chemie (International ed. in English) · 2022Article
- Hydroxylamine-mediated C-C amination via an aza-hock rearrangement.Nature communications · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anilines are fundamental motifs in various chemical contexts, and are widely used in the industrial production of fine chemicals, polymers, agrochemicals and pharmaceuticals. A recent development for the synthesis of anilines uses the primary amination of C-H bonds in electron-rich arenes. However, there are limitations to this strategy: the amination of electron-deficient arenes remains a challenging task and the amination of electron-rich arenes has a limited control over regioselectivity-the formation of meta-aminated products is especially difficult. Here we report a site-directed C-C bond primary amination of simple and readily available alkylarenes or benzyl alcohols for the direct and efficient preparation of anilines. This chemistry involves a novel C-C bond transformation and offers a versatile protocol for the synthesis of substituted anilines. The use of O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.