ArticleScientific reports2018
An atypical RNA silencing suppression strategy provides a snapshot of the evolution of sweet potato-infecting potyviruses.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Role of Bean Yellow Mosaic Virus P1 and HC-Pro in Enhancing Gene Expression and Suppressing RNA Silencing inLife (Basel, Switzerland) · 2025Article
- New isolate of sweet potato virus 2 from Ipomoea nil: molecular characterization, codon usage bias, and phylogenetic analysis based on complete genome.Virology journal · 2024Article
- High-throughput characterization and phenotyping of resistance and tolerance to virus infection in sweetpotato.Virus research · 2024Article
- Soybean 40S Ribosomal Protein S8 (GmRPS8) Interacts with 6K1 Protein and Contributes to Soybean Susceptibility toViruses · 2023Article
- Modification of the N-terminal FWKG-αH1 element of potyviral HC-Pro affects its multiple functions and generates effective attenuated mutants for cross-protection.Molecular plant pathology · 2022Article
- Insight into aphid mediatedFrontiers in microbiology · 2022Review
- An Importin-β-like Protein fromViruses · 2021Article
- P1 ofJournal of virology · 2021Article
- Biological and Molecular Characterization of Two Closely Related Arepaviruses and Their Antagonistic Interaction inFrontiers in microbiology · 2021Article
- Long-Term Efficacy and Safety of RNAi-Mediated Virus Resistance in 'HoneySweet' Plum.Frontiers in plant science · 2021Article
- A Newly Identified Virus in the FamilyJournal of virology · 2020Article
- Citrus Leprosis Virus C Encodes Three Proteins With Gene Silencing Suppression Activity.Frontiers in microbiology · 2020Article
- A Spontaneous Complementary Mutation Restores the RNA Silencing Suppression Activity of HC-Pro and the Virulence of Sugarcane Mosaic Virus.Frontiers in plant science · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Plant viruses usually encode proteins with RNA silencing suppression (RSS) activity to counteract plant defenses. In Potyvirus, the largest genus in the family Potyviridae, this role is taken over by the multifunctional HCPro, also involved in aphid transmission, polyprotein processing and virion formation. Recently, the large P1 of Sweet potato feathery mottle virus (SPFMV) was characterized finding an extra ORF produced after polymerase slippage, which originates the product P1N-PISPO. Transient expression assays showed that SPFMV P1 and P1N-PISPO presented RSS activity, while HCPro did not. In this work, we analyze possible differences between HCPro of SPFMV and other potyviruses, testing HCPro RSS activity in a transient expression assay, and using a Plum pox virus-based system to test the ability of SPFMV P1N-PISPO and HCPro to serve as RNA silencing suppressors in the context of a viral infection. Our results indicate that not only P1 and P1N-PISPO, but also HCPro display RSS activity when expressed in a suitable context, stressing the importance of the selected experimental system for testing anti-silencing capacity of proteins. The presence of multiple viral silencing suppressors in SPFMV adds complexity to an already intricate RSS system, and provides insight into the hypothetical evolution of sweet potato-infecting potyvirids.
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