Evidence map›Paper›PMID 30373884›Full record

Trial reportBlood2018

Subclonal

Vallari Shah, David C Johnson, Amy L Sherborne, Sidra Ellis, Frances M Aldridge, Julie Howard-Reeves, Farzana Begum, Amy Price, Jack Kendall, Laura Chiecchio and 13 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Guideline
  2. Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Pooled it
  3. Trial
  4. Defining High-Risk Disease Biology in Multiple Myeloma: A Narrative Review.Blood and lymphatic cancer : targets and therapy · 2026
    Review
  5. Article
  6. Article
  7. Frontiers in medicine · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. [Progress in clonal evolution of multiple myeloma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 3 countries.

Vallari ShahDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
David C JohnsonDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Amy L SherborneDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Sidra EllisDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Frances M AldridgeCentre for Molecular Pathology, The Royal Marsden Hospital, London, United Kingdom.
Julie Howard-ReevesCentre for Molecular Pathology, The Royal Marsden Hospital, London, United Kingdom.
Farzana BegumDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Amy PriceDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Jack KendallDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Laura ChiecchioWessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, United Kingdom.ORCID 0000-0002-6221-8617
Suvi SavolaMRC-Holland, Amsterdam, Netherlands.
Matthew W JennerDepartment of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Mark T DraysonInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Roger G OwenHaematological Malignancy Diagnostic Service, St. James's University Hospital, Leeds, United Kingdom.
Walter M GregoryClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, Leeds, United Kingdom.
Gareth J MorganMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR.
Faith E DaviesMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR.
Richard S HoulstonDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-5268-0242
Gordon CookLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom; and.
David A CairnsClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, Leeds, United Kingdom.
Graham JacksonDepartment of Haematology, University of Newcastle, Newcastle upon Tyne, United Kingdom.
Martin F KaiserDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-3677-4804
National Cancer Research Institute Haematology Clinical Studies Group
Institute of Cancer Research · GBRoyal Marsden Hospital · GBUniversity of Arkansas for Medical Sciences · USMRC Holland (Netherlands) · NLNewcastle University · GBSt James's University Hospital · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Birmingham · GBUniversity of Leeds · GBWessex Regional Genetics Laboratory · GB

Funding

Cancer Research UK C2470/A12136Cancer Research UK C2470/A17761
6 · The paper itself

Abstract

Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of

Indexed as

Gene DeletionGene DosageGenomic InstabilityDisease-Free SurvivalFemaleHumansMaleMultiple MyelomaSurvival RateTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID30373884
PMCPMC6533595
OpenAlexW2898904960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.