ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4
Abstract read
In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Exploring Key Regulators of Mitochondrial Dynamics and Immune Response in SARS-CoV-2 Infection.Viruses · 2026Article
- Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma.Nature communications · 2026Article
- Proteomic signatures and mitochondrial dysfunctions in peripheral T cells reveal novel ınsights into Alzheimer's disease.Scientific reports · 2025Article
- Metabolism-driven posttranslational modifications and immune regulation: Emerging targets for immunotherapy.Science advances · 2025Review
- Viral Reprogramming of Nucleotide Synthesis and Its Impact on Viral Infection.Journal of medical virology · 2025Review
- How (Ultra-)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases.ACR open rheumatology · 2025Review
- Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies.Frontiers in immunology · 2025Review
- Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system.Free radical biology & medicine · 2024Article
- A Pipeline for Dynamic Analysis of Mitochondrial Content in Developing T Cells: Bridging the Gap Between High-Throughput Flow Cytometry and Single-Cell Microscopy Analysis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Actives from the Micro-Immunotherapy Medicine 2LMIREGJournal of inflammation research · 2024Article
- A gene network database for the identification of key genes for diagnosis, prognosis, and treatment in sepsis.Scientific reports · 2023Article
- STAT3 modulates CD4Aging cell · 2023Article
- Metabolic modulation of mitochondrial mass during CD4Cell chemical biology · 2023Article
- Boosting NAD: An opportunity for metabolic reprogramming of Th17 cells in psoriatic disease.Cell reports. Medicine · 2023Article
- Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity.Science advances · 2023Article
- Age-associated remodeling of T cell immunity and metabolism.Cell metabolism · 2023Review
- Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV.Brain, behavior, and immunity · 2023Article
- Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease.Frontiers in immunology · 2023Review
- Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels.Molecular systems biology · 2022Article
- Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4Cell death & disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Billur AkkayaLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-6808-3776
Alexander S RoeslerLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.ORCID 0000-0001-5768-1589
Pietro MiozzoLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.ORCID 0000-0003-3486-4061
Brandon P TheallLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.ORCID 0000-0003-3852-5139
Jafar Al SouzLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-2345-2803
Margery G SmelkinsonResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-7777-5574
Juraj KabatResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Javier TrabaCardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and.
Michael N SackCardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and.ORCID 0000-0002-3411-0000
Joseph A BrzostowskiLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.ORCID 0000-0003-0257-3905
Mirna PenaLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.
David W DorwardResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.ORCID 0000-0002-1710-731X
Susan K PierceLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852.ORCID 0000-0001-7261-3437
Munir AkkayaLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; munir.akkaya@nih.gov.ORCID 0000-0002-9949-9424
National Institutes of Health · US
Funding
The Initiation of B-Cell SignalingZIAAI000898 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PIERCE, SUSAN · 2009 to 2025
$30.9MControl of Autoimmunity by Regulatory T CellsZIAAI000224 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHEVACH, ETHAN · 2009 to 2025
$13.4MIntracellular Trafficking and Signaling Of The B-cell Antigen ReceptorZIAAI000899 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PIERCE, SUSAN · 2009 to 2018
$5.5MIntracellular Trafficking Of The B-cell Antigen ReceptorZ01AI000899 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PIERCE, SUSAN · 2001 to 2008
$625kIntramural NIH HHS Z01 AI000899
Abstract
Activation of CD4
Indexed as
Time FactorsAnimalsCD4-Positive T-LymphocytesCells, CulturedEnergy MetabolismFemaleGlutamate Plasma Membrane Transport ProteinsGlycolysisLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicMitochondriaReactive Oxygen SpeciesSignal TransductionGlutamate Plasma Membrane Transport ProteinsReactive Oxygen Species
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.