Evidence map›Paper›PMID 30373844›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Quantifying resilience of humans and other animals.

Marten Scheffer, J Elizabeth Bolhuis, Denny Borsboom, Timothy G Buchman, Sanne M W Gijzel, Dave Goulson, Jan E Kammenga, Bas Kemp, Ingrid A van de Leemput, Simon Levin and 5 more

Registry-linked trialAbstract readEditorial
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07773571 (Development of an ICU Physiological State Space Monitor Based on the ICCA Database), which is not on this map. Cited by 131 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07773571 active not recruitingnot on this mapstarted 2026, after this paper: background citation

Development of an ICU Physiological State Space Monitor Based on the ICCA Database: A Single-Center Retrospective Observational Study

TypeobservationalSponsorShanghai Zhongshan HospitalRan2026 to 2029Enrolled60,000ConditionsCritical IllnessArmsMultidimensional ICU Physiological State and Trajectory Features
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Early warning signals for loss of control in complex systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Emerging design principles for environmental, economic, and equity successes in land conservation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Review
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  20. The Impairment of Body Condition Transiently Increases Oxidative Stress: A Dietary Restriction Experiment in Partridges.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025
    Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marten SchefferEnvironmental Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands; Marten.Scheffer@wur.nl.
J Elizabeth BolhuisAdaptation Physiology Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Denny BorsboomDepartment of Psychology, University of Amsterdam, 1018 WX Amsterdam, The Netherlands.
Timothy G BuchmanEmory Critical Care Center, Emory University, Atlanta, GA 30322.
Sanne M W GijzelEnvironmental Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Dave GoulsonSchool of Life Sciences, University of Sussex, Brighton BN1 9RH, United Kingdom.
Jan E KammengaLaboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands.
Bas KempAdaptation Physiology Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Ingrid A van de LeemputEnvironmental Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Simon LevinDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544.
Carmel Mary MartinDepartment of Medicine, Monash Health Community, Clayton, VIC 3168, Australia.
René J F MelisDepartment of Geriatrics, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Egbert H van NesEnvironmental Sciences Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
L Michael RomeroDepartment of Biology, Tufts University, Medford, MA 02155.
Marcel G M Olde RikkertDepartment of Geriatrics, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All life requires the capacity to recover from challenges that are as inevitable as they are unpredictable. Understanding this resilience is essential for managing the health of humans and their livestock. It has long been difficult to quantify resilience directly, forcing practitioners to rely on indirect static indicators of health. However, measurements from wearable electronics and other sources now allow us to analyze the dynamics of physiology and behavior with unsurpassed resolution. The resulting flood of data coincides with the emergence of novel analytical tools for estimating resilience from the pattern of microrecoveries observed in natural time series. Such dynamic indicators of resilience may be used to monitor the risk of systemic failure across systems ranging from organs to entire organisms. These tools invite a fundamental rethinking of our approach to the adaptive management of health and resilience.

Indexed as

Adaptation, PhysiologicalAnimalsConservation of Natural ResourcesHealthHolistic HealthHumansResilience, Psychologicalaginghealthlivestockresiliencetipping points

Identifiers

PMID30373844
PMCPMC6255191

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.