Evidence map›Paper›PMID 30373839›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Engineering yeast endosymbionts as a step toward the evolution of mitochondria.

Angad P Mehta, Lubica Supekova, Jian-Hua Chen, Kersi Pestonjamasp, Paul Webster, Yeonjin Ko, Scott C Henderson, Gerry McDermott, Frantisek Supek, Peter G Schultz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Facultative mutualism betweenISME communications · 2026
    Article
  7. First Evidence of Metabolically Active Intracellular Bacteria inJournal of agricultural and food chemistry · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Determination of the genome-scale metabolic network ofFrontiers in bioengineering and biotechnology · 2025
    Article
  12. Article
  13. Article
  14. Synthesis at the Interface of Chemistry and Biology.Accounts of chemical research · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Evolution and synthetic biology.Current opinion in microbiology · 2023
    Review
  19. Experimental evolution for cell biology.Trends in cell biology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angad P MehtaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Lubica SupekovaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Jian-Hua ChenDepartment of Anatomy, School of Medicine, University of California, San Francisco, CA 94158.
Kersi PestonjamaspCore Microscopy Facility, The Scripps Research Institute, La Jolla, CA 92037.
Paul WebsterDepartment of Advanced Imaging and Microscopy, Oak Crest Institute of Science, Monrovia, CA 91016.
Yeonjin KoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Scott C HendersonCore Microscopy Facility, The Scripps Research Institute, La Jolla, CA 92037.
Gerry McDermottDepartment of Anatomy, School of Medicine, University of California, San Francisco, CA 94158.
Frantisek SupekDepartment of General Medical Biology, Genomics Institute of the Novartis Research Foundation, La Jolla, CA 92121 fsupek@gnf.org schultz@scripps.edu.
Peter G SchultzDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; fsupek@gnf.org schultz@scripps.edu.

Funding

TrainingP41GM103445 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARABELL, CAROLYN A · 2012 to 2019
$8.2M
NIGMS NIH HHS P41 GM103445
6 · The paper itself

Abstract

It has been hypothesized that mitochondria evolved from a bacterial ancestor that initially became established in an archaeal host cell as an endosymbiont. Here we model this first stage of mitochondrial evolution by engineering endosymbiosis between

Indexed as

Adenosine TriphosphateAmino Acid SequenceBioengineeringBiological EvolutionEscherichia coliMitochondriaModels, BiologicalSaccharomyces cerevisiaeSymbiosisThiamineAdenosine TriphosphateThiamineADP/ATP translocaseendosymbiotic theoryevolutionmitochondria

Identifiers

PMID30373839
PMCPMC6243291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.