ArticleProceedings of the National Academy of Sciences of the United States of America2018
Ab initio structure determination from experimental fluctuation X-ray scattering data.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Femtosecond X-ray cross-correlation analysis of disordered crystals forming in a supercooled atomic liquid.IUCrJ · 2025Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- TheJournal of applied crystallography · 2024Article
- A workflow for single-particle structure determination via iterative phasing of rotational invariants in fluctuation X-ray scattering.Journal of applied crystallography · 2024Article
- Structure determination using high-order spatial correlations in single-particle X-ray scattering.IUCrJ · 2024Article
- 3D-printed sheet jet for stable megahertz liquid sample delivery at X-ray free-electron lasers.IUCrJ · 2023Article
- Thinner than a knife's edge: 3D-printed liquid sheet jet technology for solution phase XFEL experiments.IUCrJ · 2023Article
- Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS).Communications biology · 2023Article
- A comparison of deep-learning-based inpainting techniques for experimental X-ray scattering.Journal of applied crystallography · 2022Article
- Chemical effects on the dynamics of organic molecules irradiated with high intensity x rays.Structural dynamics (Melville, N.Y.) · 2022Article
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- Random conical tilt reconstruction without particle picking in cryo-electron microscopy.Acta crystallographica. Section A, Foundations and advances · 2022Article
- Super-resolution multi-reference alignment.Information and inference : a journal of the IMA · 2022Article
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- Protein large-scale motions revealed by quantum beams: A new era in understanding protein dynamics.Biophysics and physicobiology · 2022Article
- Cross-correlation analysis of X-ray photon correlation spectroscopy to extract rotational diffusion coefficients.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- GPU-accelerated multitiered iterative phasing algorithm for fluctuation X-ray scattering.Journal of applied crystallography · 2021Article
- Steerable ePCA: Rotationally Invariant Exponential Family PCA.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2020Article
- Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses.Nature communications · 2020Article
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Abstract
Fluctuation X-ray scattering (FXS) is an emerging experimental technique in which X-ray solution scattering data are collected from particles in solution using ultrashort X-ray exposures generated by a free-electron laser (FEL). FXS experiments overcome the low data-to-parameter ratios associated with traditional solution scattering measurements by providing several orders of magnitude more information in the final processed data. Here we demonstrate the practical feasibility of FEL-based FXS on a biological multiple-particle system and describe data-processing techniques required to extract robust FXS data and significantly reduce the required number of snapshots needed by introducing an iterative noise-filtering technique. We showcase a successful ab initio electron density reconstruction from such an experiment, studying the
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