Evidence map›Paper›PMID 30373801›Full record

ArticleAntimicrobial agents and chemotherapy2019

Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Pranita D Tamma, Yunfan Fan, Yehudit Bergman, Geo Pertea, Abida Q Kazmi, Shawna Lewis, Karen C Carroll, Michael C Schatz, Winston Timp, Patricia J Simner

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Metagenomic next-generation sequencing: new horizons in microbiology.Frontiers in cellular and infection microbiology · 2026
    Review
  4. A model for predicting bacteremia species based on host immune response.Frontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Article
  7. Is Carbapenem Therapy Necessary for the Treatment of Non-CTX-M Extended-Spectrum β-Lactamase-Producing Enterobacterales Bloodstream Infections?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Observational
  8. Laboratory tools for the direct detection of bacterial respiratory infections and antimicrobial resistance: a scoping review.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
    Article
  9. Article
  10. An NDM-ProducingOpen forum infectious diseases · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Successful Treatment of PersistentOpen forum infectious diseases · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pranita D TammaJohns Hopkins University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA.
Yunfan FanJohns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, USA.
Yehudit BergmanJohns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.
Geo PerteaJohns Hopkins University, Department of Computer Science, Baltimore, Maryland, USA.
Abida Q KazmiJohns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.
Shawna LewisJohns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.
Karen C CarrollJohns Hopkins University School of Medicine, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA.
Michael C SchatzJohns Hopkins University, Department of Computer Science, Baltimore, Maryland, USA.
Winston TimpJohns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, USA.ORCID 0000-0003-2083-6027
Patricia J SimnerJohns Hopkins University School of Medicine, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA psimner1@jhmi.edu.

Funding

Computational Methods for Genome Assembly, Transcript Assembly, and Variant DiscoveryR01HG006677 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI SALZBERG, STEVEN L. · 2011 to 2025
$10.7M
Nanopore based profiling of epigenetic stateR01HG009190 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI TIMP, WINSTON GEORGE · 2017 to 2024
$4.8M
The Use of MALDI TOF for the Rapid Detection of Carbapenemases from Clinical IsolatesK23AI127935 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TAMMA, PRANITA · 2017 to 2020
$734k
Real-Time Whole Genome Sequencing Analysis of Carbapenemase-Producing Organisms in the Non-Outbreak Hospital SettingR21AI130608 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SIMNER, PATRICIA · 2017 to 2018
$449k
CIHRNHGRI NIH HHS R01 HG006677NHGRI NIH HHS R01 HG009190NIAID NIH HHS K23 AI127935NIAID NIH HHS R21 AI130608
6 · The paper itself

Abstract

Standard antimicrobial susceptibility testing (AST) approaches lead to delays in the selection of optimal antimicrobial therapy. Here, we sought to determine the accuracy of antimicrobial resistance (AMR) determinants identified by Nanopore whole-genome sequencing in predicting AST results. Using a cohort of 40 clinical isolates (21 carbapenemase-producing carbapenem-resistant

Indexed as

Genome, BacterialPhenotypeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsCohort StudiesComputational BiologyDrug Resistance, Multiple, BacterialGene ExpressionGene LibraryHumansKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPolymorphism, Single NucleotideAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsantibiotic resistanceantimicrobial resistanceIlluminaWGS

Identifiers

PMID30373801
PMCPMC6325187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.