Evidence map›Paper›PMID 30373796›Full record

ArticleAntimicrobial agents and chemotherapy2019

Spontaneous Mutational Frequency and

Ryan K Shields, Ellen G Kline, Kelley R Healey, Milena Kordalewska, David S Perlin, M Hong Nguyen, Cornelius J Clancy

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Decoding resistance inFrontiers in cellular and infection microbiology · 2026
    Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Antifungal susceptibility, molecular epidemiology, and clinical risk factors ofFrontiers in cellular and infection microbiology · 2024
    Article
  11. Baicalin promotes β-1,3-glucan exposure inFrontiers in cellular and infection microbiology · 2024
    Article
  12. Review
  13. Journal of fungi (Basel, Switzerland) · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Candidiasis byJournal of fungi (Basel, Switzerland) · 2021
    Article
  20. Emergence of resistantJAC-antimicrobial resistance · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ryan K ShieldsDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ellen G KlineDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kelley R HealeyPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Milena KordalewskaPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
David S PerlinPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
M Hong NguyenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
Cornelius J ClancyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rutgers, The State University of New Jersey · USUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · USVA Pittsburgh Healthcare System · US

Funding

Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasisK08AI114883 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2015 to 2019
$858k
Imaging and PK-PD of micafungin at sites of Candida glabrata infection in vivoR21AI121555 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLANCY, CORNELIUS J · 2016 to 2017
$444k
NIAID NIH HHS K08 AI114883NIAID NIH HHS R01 AI109025NIAID NIH HHS R21 AI121555
6 · The paper itself

Abstract

Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in

Indexed as

AnidulafunginAntifungal AgentsCandida glabrataCandidiasisCandidiasis, InvasiveCaspofunginDrug Resistance, FungalFungal ProteinsGene ExpressionGenetic LociGlucosyltransferasesHumansMicafunginMicrobial Sensitivity TestsMutation RateAnidulafunginAntifungal AgentsCaspofunginFungal ProteinsGlucosyltransferasesMicafunginanidulafunginCandida glabratacaspofunginechinocandinFKSmicafunginmutational frequency

Identifiers

PMID30373796
PMCPMC6325211
OpenAlexW2898334442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.