Evidence map›Paper›PMID 30373791›Full record

Trial reportAntimicrobial agents and chemotherapy2019

Outcomes by MIC Values for Patients Treated with Isavuconazole or Voriconazole for Invasive Aspergillosis in the Phase 3 SECURE and VITAL Trials.

David R Andes, Mahmoud A Ghannoum, Pranab K Mukherjee, Laura L Kovanda, Qiaoyang Lu, Mark E Jones, Anne Santerre Henriksen, Christopher Lademacher, William W Hope

Open access · hybridAbstract readClinical Trial, Phase III
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Guideline
  2. Isavuconazole as Primary Antifungal Prophylaxis in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-label, Prospective, Phase 2 Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Trial
  3. Real-life use of isavuconazole in Spanish children and adolescents.The Journal of antimicrobial chemotherapy · 2026
    Article
  4. Systemic Antifungal Therapy for Invasive Pulmonary Infections.Journal of fungi (Basel, Switzerland) · 2023
    Review
  5. New Perspectives on Antimicrobial Agents: Isavuconazole.Antimicrobial agents and chemotherapy · 2022
    Review
  6. Clinical utility of antifungal susceptibility testing.JAC-antimicrobial resistance · 2022
    Review
  7. Rhinosinus Mucormycosis with Drug-induced Pancytopenia in an Immunocompromised Severe COVID-19 Patient: A Success.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Isavuconazole Diffusion in Infected Human Brain.Antimicrobial agents and chemotherapy · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

David R AndesUniversity of Wisconsin-Madison, Madison, Wisconsin, USA dra@medicine.wisc.edu.
Mahmoud A GhannoumCase Western Reserve University, Cleveland, Ohio, USA.
Pranab K MukherjeeCase Western Reserve University, Cleveland, Ohio, USA.
Laura L KovandaAstellas Pharma Global Development, Inc., Northbrook, Illinois, USA.ORCID 0000-0002-4493-4652
Qiaoyang LuAstellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
Mark E JonesBasilea Pharmaceutica International Ltd., Basel, Switzerland.
Anne Santerre HenriksenBasilea Pharmaceutica International Ltd., Basel, Switzerland.
Christopher LademacherAstellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
William W HopeUniversity of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-6187-878X
Astellas Pharma (United States) · USBasilea Pharmaceutica (Switzerland) · CHCase Western Reserve University · USUniversity of Liverpool · GBUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This pooled analysis evaluated the relationship of isavuconazole and voriconazole MICs of

Indexed as

Antifungal AgentsAspergillosisAspergillusHumansInvasive Fungal InfectionsMicrobial Sensitivity TestsNitrilesPyridinesTriazolesVoriconazoleAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolesVoriconazoleclinical trialisavuconazoleisavuconazonium sulfateMICvoriconazole

Identifiers

PMID30373791
PMCPMC6325202
OpenAlexW2898579516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.