Evidence map›Paper›PMID 30373750›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019

A Novel Engineered Small Protein for Positron Emission Tomography Imaging of Human Programmed Death Ligand-1: Validation in Mouse Models and Human Cancer Tissues.

Arutselvan Natarajan, Chirag B Patel, Sindhuja Ramakrishnan, Paramjyot S Panesar, Steven R Long, Sanjiv S Gambhir

Abstract readValidation StudyVideo-Audio Media
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cell Model for Testing Pharmaceuticals Targeting Human PD-L1.Sovremennye tekhnologii v meditsine · 2024
    Article
  6. Review
  7. Review
  8. Review
  9. Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  10. Article
  11. FN3 linked nanobubbles as a targeted contrast agent for US imaging of cancer-associated human PD-L1.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. PET Imaging of TIGIT Expression on Tumor-Infiltrating Lymphocytes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  16. Review
  17. Journal for immunotherapy of cancer · 2020
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arutselvan NatarajanMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California.
Chirag B Patel *Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California.
Sindhuja Ramakrishnan *Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California.
Paramjyot S PanesarMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California.
Steven R LongDepartment of Pathology, Stanford University, Stanford, California.
Sanjiv S GambhirMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California. sgambhir@stanford.edu.
Stanford University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
Modeling and Predicting Therapeutic Resistance of CancerU01CA188383 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W, GAMBHIR, SANJIV S · 2014 to 2018
$3.2M
A Novel Positron Emission Tomography Strategy for Early Detection and Treatment Monitoring of Graft-versus-host DiseaseR01CA201719 · NCI · STANFORD UNIVERSITY · PI JAMES, MICHELLE LOUISE · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA124435NCI NIH HHS P50 CA114747NCI NIH HHS R01 CA201719NCI NIH HHS U01 CA188383
6 · The paper itself

Abstract

purposeTo design and evaluate a small engineered protein binder targeting human programmed death-1 ligand (hPD-L1)

resultsFN3

conclusionsThe

Indexed as

AdultAgedAnimalsB7-H1 AntigenCell Line, TumorCopper RadioisotopesDisease Models, AnimalFemaleFibronectin Type III DomainHumansMaleMiceMolecular ImagingMolecular ProbesNeoplasmsPositron Emission Tomography Computed TomographyB7-H1 AntigenCD274 protein, humanCopper-64Copper RadioisotopesMolecular ProbesRadiopharmaceuticalsRecombinant Proteins

Identifiers

PMID30373750
PMCPMC6420852
OpenAlexW2899447982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.