Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2018
Awake Multimodal Phenotyping for Prediction of Oral Appliance Treatment Outcome.
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The predictive value of mandibular advancement maneuvers during drug-induced sleep endoscopy for treatment success of oral appliance treatment in obstructive sleep apnea: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Effects of mandibular advancement devices on upper airway dimensions in obstructive sleep apnea: responders versus non-responders.Clinical oral investigations · 2023Trial
- Polysomnographic Endotyping to Select Patients with Obstructive Sleep Apnea for Oral Appliances.Annals of the American Thoracic Society · 2019Trial
- Craniofacial photography for detection of positional obstructive sleep apnoea.Sleep and biological rhythms · 2026Article
- Association of Skeletal Facial Pattern With Treatment Response of Obstructive Sleep Apnoea Using Mandibular Advancement Devices - A Cluster Analysis.Journal of oral rehabilitation · 2025Article
- Evaluating the effectiveness of mandibular advancement devices in treating very severe obstructive sleep apnea: a retrospective cohort study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Upper airway morphology in adults with positional obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Effect of mandibular advancement splint therapy on cardiac autonomic function in obstructive sleep apnoea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Effectiveness of Mandibular Advancement Devices in Positional OSA Patients: A Retrospective Analysis of Predictive Variables in a Sample of Adult Patients.Sleep science (Sao Paulo, Brazil) · 2024Article
- Predictive factors of therapeutic response according to craniofacial skeletal biotype in patients with sleep apnea syndrome using mandibular advancement devices: a pilot study.The Angle orthodontist · 2024Article
- Indications for Dental Specialists for Treating Obstructive Sleep Apnea with Mandibular Advancement Devices: A Narrative Review.International journal of dentistry · 2024Review
- Self-reported improvement in obstructive sleep apnea symptoms compared to treatment response with mandibular advancement device therapy: a retrospective study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Multimodal phenotypic labelling using drug-induced sleep endoscopy, awake nasendoscopy and computational fluid dynamics for the prediction of mandibular advancement device treatment outcome: a prospective study.Journal of sleep research · 2022Article
- Optimizing Mandibular Advancement Maneuvers during Sleep Endoscopy with a Titratable Positioner: DISE-SAM Protocol.Journal of clinical medicine · 2022Article
- Prediction of Mandibular Advancement Device Response Using CPAP Pressure in Different Polysomnographic Phenotypes.Nature and science of sleep · 2022Article
- Acoustic pharyngometry - A new method to facilitate oral appliance therapy.Journal of oral rehabilitation · 2021Article
- A consideration of factors affecting palliative oral appliance effectiveness for obstructive sleep apnea: a scoping review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- The relationship between specific nasopharyngoscopic features and treatment deterioration with mandibular advancement devices: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Oral Appliance Therapy for Obstructive Sleep Apnoea: State of the Art.Journal of clinical medicine · 2019Review
- Predicting a Successful Response to Oral Appliance Therapy: Advancing Knowledge One Model at a Time.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesAn oral appliance (OA) is a validated treatment for obstructive sleep apnea (OSA). However, therapeutic response is not certain in any individual and is a clinical barrier to implementing this form of therapy. Therefore, accurate and clinically applicable prediction methods are needed. The goal of this study was to derive prediction models based on multiple awake assessments capturing different aspects of the pharyngeal response to mandibular advancement. We hypothesized that a multimodal model would provide robust prediction.
methodsPatients with OSA (apnea-hypopnea index [AHI] > 10 events/h) were recruited for treatment with a customized OA (n = 142, 59% male). Participants underwent facial photography (craniofacial structure), spirometry (mid-inspiratory flow at 50% vital capacity [MIF
resultsCraniofacial structure and flow-volume loops predicted treatment response. Accuracy of the prediction models (area under the receiver operating characteristic curve) for each criterion were 0.90 (criterion 1), 0.79 (criterion 2), and 0.78 (criterion 3). However, these prediction models including phenotypic assessments did not provide a statistically significant improvement over clinical predictors only.
conclusionsMultimodal awake phenotyping does not enhance OA treatment outcome prediction. These office-based, awake assessments have limited utility for robust clinical prediction models. Future work should focus on sleep-related assessments. COMMENTARY: A commentary on this article appears in this issue on page 1837. CLINICAL
trial registrationRegistry: Australian New Zealand Clinical Trials Registry, Title: Multimodal phenotyping for the prediction of oral appliance treatment outcome in obstructive sleep apnoea, Identifier: ACTRN12611000409976, URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=336663.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.