Evidence map›Paper›PMID 30373658›Full record

ArticleVeterinary research2018

Characterization of the zinc metalloprotease of Streptococcus suis serotype 2.

Audrey Dumesnil, Jean-Philippe Auger, David Roy, Désirée Vötsch, Maren Willenborg, Peter Valentin-Weigand, Pyong Woo Park, Daniel Grenier, Nahuel Fittipaldi, Josée Harel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Deletion of theMicroorganisms · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Audrey DumesnilSwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
Jean-Philippe AugerSwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
David RoySwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
Désirée VötschInstitute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany.
Maren WillenborgInstitute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany.
Peter Valentin-WeigandInstitute for Microbiology, University of Veterinary Medicine Hannover, Hannover, Germany.
Pyong Woo ParkBoston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel GrenierSwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
Nahuel FittipaldiPublic Health Ontario Laboratory Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Josée HarelSwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada.
Marcelo GottschalkSwine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada. marcelo.gottschalk@umontreal.ca.ORCID http://orcid.org/0000-0002-2196-2212
Université de Montréal · CAUniversity of Veterinary Medicine Hannover, Foundation · DEBoston Children's Hospital · USCegep de Saint Hyacinthe · CAUniversité Laval · CAUniversity of Toronto · CA

Funding

Natural Sciences and Engineering Research Council of Canada 04435
6 · The paper itself

Abstract

Streptococcus suis is a swine pathogen and zoonotic agent responsible for meningitis and septic shock. Although several putative virulence factors have been described, the initial steps of the S. suis pathogenesis remain poorly understood. While controversial results have been reported for a S. suis serotype 2 zinc metalloprotease (Zmp) regarding its IgA protease activity, recent phylogenetic analyses suggested that this protein is homologous to the ZmpC of Streptococcus pneumoniae, which is not an IgA protease. Based on the previously described functions of metalloproteases (including IgA protease and ZmpC), different experiments were carried out to study the activities of that of S. suis serotype 2. First, results showed that S. suis, as well as the recombinant Zmp, were unable to cleave human IgA

Indexed as

AnimalsDNA, BacterialGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicMetalloendopeptidasesMiceProtein DomainsSerine EndopeptidasesSerogroupStreptococcal InfectionsStreptococcus suisVirulenceDNA, BacterialIgA-specific serine endopeptidaseMetalloendopeptidasesSerine Endopeptidases

Identifiers

PMID30373658
PMCPMC6206940
OpenAlexW2898998450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.