Evidence map›Paper›PMID 30373650›Full record

ArticleTrials2018

Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial.

Marcela Leticia Leal Gonçalves, Ana Carolina Costa da Mota, Alessandro Melo Deana, Guelton Hirano Guedes, Lisyanne Araújo de Souza Cavalcante, Renato Araújo Prates, Anna Carolina Ratto Tempestini Horliana, Christiane Pavani, Lara Jansiski Motta, Greice de Brito Bitencourt and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03346460 (Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03346460 phase2unknown statusnot on this map

Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis: a Clinical and Microbiological Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2018 to 2018Enrolled45ConditionsHalitosisArmsTongue Scraping, aPDT, Tongue scraper and aPDT
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Marcela Leticia Leal GonçalvesBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Ana Carolina Costa da MotaBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Alessandro Melo DeanaBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Guelton Hirano GuedesBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Lisyanne Araújo de Souza CavalcanteUniversidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Renato Araújo PratesBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Anna Carolina Ratto Tempestini HorlianaBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Christiane PavaniBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Lara Jansiski MottaBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Greice de Brito BitencourtRehabilitation Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Kristianne Porta Santos FernandesBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Monica da Consolação Canuto SalgueiroRehabilitation Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Raquel Agnelli Mesquita-FerrariRehabilitation Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Daniela Fátima Teixeira da SilvaBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.
Cristiane Miranda FrançaBiomaterials and Biomechanics, School of Dentistry, Oregon Health and Science University, 2730 S.W. Moody Ave, Portland, OR, 97201, USA.
Sandra Kalil BussadoriBiophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil. sandra.skb@gmail.com.ORCID http://orcid.org/0000-0002-9853-1138
Universidade Nove de Julho · BROregon Health & Science University · US

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 306324/2017-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/19983-5
6 · The paper itself

Abstract

backgroundHalitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as "urucum" is a plant native to Brazil. The seeds are used to produce a dye that is largely used in the food, textile, paint and cosmetic industries. The aim of this study is to verify whether aPDT with Bixa orellana extract and blue light-emitting diodes (LEDs) is effective in reducing halitosis. This method will also be compared with tongue scraping, the most commonly used conventional method for tongue coating removal, and the association of both methods will be evaluated. METHODS/

designA randomized clinical trial will be conducted at the dental clinic of the Universidade Nove de Julho. Thirty-nine patients will be divided by block randomization into three groups (n = 13) according to the treatment to be performed. In Group 1, tongue scraping will be performed by the same operator in all patients for analysis of the immediate results. Patients will also be instructed on how to use the scraper at home. Group 2 will be treated with aPDT with Bixa orellana extract and the LED light curing device: Valo Cordless Ultradent®. Six points in the tongue dorsum with a distance of 1 cm between them will be irradiated. The apparatus will be pre-calibrated at wavelength 395-480 nm for 20 s and 9.6 J per point. In Group 3, patients will be submitted to the tongue scraping procedure, as well as to the previously explained aPDT. Oral air collection with the Oral Chroma™ and microbiological collections of the tongue coating shall be done before, immediately after and 7 days after treatment for comparison. DISCUSSION: Halitosis treatment is a topic that still needs attention. The results of this trial could support decision-making by clinicians regarding aPDT using blue LEDs for treating halitosis on a daily basis, as most dentists already have this light source in their offices.

trial registrationClinicalTrials.gov, NCT03346460 . Registered on 17 November 2017.

Indexed as

BixaceaeCuring Lights, DentalAdolescentAdultBrazilFemaleHalitosisHumansMalePhotochemotherapyPhotosensitizing AgentsPlant ExtractsRandomized Controlled Trials as TopicTime FactorsTongueTreatment OutcomePhotosensitizing AgentsPlant ExtractsBixa orellanaHalitosisPhotodynamic therapy

Identifiers

PMID30373650
PMCPMC6206672
OpenAlexW2899107545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.