ArticleCardiovascular ultrasound2018
Long-term follow-up in adults after tetralogy of Fallot repair.
Article in Cardiovascular ultrasound, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Minimally invasive pulmonary valve replacement via left anterior mini-thoracotomy after Tetralogy of Fallot repair: a five-patient case series.Journal of cardiothoracic surgery · 2026Article
- Revisiting Hepatic Fibrosis Risk in Congenital Heart Disease: Insights from Non-Invasive Markers and Echocardiography.Children (Basel, Switzerland) · 2025Article
- Late presenting tetralogy of Fallot-surgical management.Indian journal of thoracic and cardiovascular surgery · 2025Review
- Right ventricular dysfunction following tetralogy of Fallot correction: anatomical determinants and therapeutic strategies.International journal of surgery (London, England) · 2025Review
- Simple ECG-based score and clinical parameters to predict right ventricular dilation in patients with repaired tetralogy of fallot.Open heart · 2025Article
- Pregnancy Considerations in Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Characterizing the Use of Exercise Testing in Repaired Tetralogy of Fallot Patients: A Multi-Institutional Survey.Pediatric cardiology · 2023Article
- Long-Term outcomes in adult patients with congenital heart disease considered for transplantation: A single center study.Clinical transplantation · 2023Article
- Health related quality of life in adults after late repair of tetralogy of fallot: experience from a low-middle income country.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Characterizing the Use of Exercise Testing in Repaired Tetralogy of Fallot Patients: A Multi-Institutional Survey.Research square · 2023Article
- Biventricular shape modes discriminate pulmonary valve replacement in tetralogy of Fallot better than imaging indices.Scientific reports · 2023Article
- Midterm prognosis following total correction of tetralogy of fallot in adult patients.Frontiers in cardiovascular medicine · 2023Article
- Syndromic and Non-Syndromic Patients with Repaired Tetralogy of Fallot: Does It Affect the Long-Term Outcome?Journal of clinical medicine · 2022Article
- Computational analysis of cardiac structure and function in congenital heart disease: Translating discoveries to clinical strategies.Journal of computational science · 2021Article
- Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot.Pediatric research · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease and the population of ToF repair survivors is growing rapidly. Adults with repaired ToF develop late complications. The aim of this study was to describe and analyze long-term follow-up of patients with repaired ToF.
methodsThis is a retrospective cohort study. Consecutive 83 patients with repaired ToF who did not undergo pulmonary valve replacement were included. Mean age of all patients was 30.5 ± 10.7. There were 49 (59%) male. Patients were divided into two groups according to the time since the repair (< 25 years and ≥ 25 years). The electrocardiographic (ECG), cardiopulmonary exercise testing (CPET), echocardiographic and cardiac magnetic resonance (CMR) data were reviewed retrospectively.
resultsIn CPET values were not significantly different in the two groups. In CMR volumes of left and right ventricles were not significantly different in the two groups. There were no differences between the groups in ventricular ejection fraction, mass of ventricles, or pulmonary regurgitation fraction. Among all the patients, ejection fraction and left and right ventricle mass, indexed pulmonary regurgitation volume measured by CMR did not correlate with the time since repair. In ECG among all the patients, ejection fraction of the RV, measured in CMR, negatively correlated with QRS duration (r = - 0.43; p < 0.001). There was a positive correlation between QRS duration and end diastolic volume of the RV (r = 0.30; p < 0.02), indexed end diastolic volume of the RV (r = 0.29; p = 0.04), RV mass (r = 0.36; p < 0.001) and left ventricle mass (r = 0.26; p = 0.04).
conclusionLong-term survival and clinical condition after surgical correction of ToF in infancy is generally good and the late functional status in ToF - operated patients could be excellent up to 25 years after the repair. QRS duration could be an utility and easy factor to assessment of right ventricular function.
trial registrationThe study protocol was approved by the local Ethics Committee. Each participant provided informed consent to participate in the study (license number 122.6120.88.2016 from 28.04.2016).
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