ArticleBMC genomics2018
Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
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- A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults.Frontiers in public health · 2023Article
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development.Genome biology · 2021Article
- Cholino-ncRNAs modulate sex-specific- and age-related acetylcholine signals.FEBS letters · 2020Review
- Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.International journal of molecular sciences · 2020Review
- Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia.Scientific reports · 2019Article
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.PloS one · 2019Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDisrupted diurnal rhythms cause accelerated aging and an increased incidence in age-related disease and morbidity. The circadian clock governs cell physiology and metabolism by controlling transcription and chromatin. The goal of this study is to further understand the mechanism of age-related changes to circadian chromatin with a focus on facultative heterochromatin and diurnal non-coding RNAs.
resultsWe performed a combined RNA-seq and ChIP-seq at two diurnal time-points for three different age groups to examine the connection between age-related changes to circadian transcription and heterochromatin in neuronal tissue. Our analysis focused on uncovering the relationships between long non-coding RNA (lncRNA) and age-related changes to histone H3 lysine 9 tri-methylation (H3K9me3), in part because the Period (Per) complex can direct facultative heterochromatin and models of aging suggest age-related changes to heterochromatin and DNA methylation. Our results reveal that lncRNAs and circadian output change dramatically with age, but the core clock genes remain rhythmic. Age-related changes in clock-controlled gene (ccg) expression indicate there are age-dependent circadian output that change from anabolic to catabolic processes during aging. In addition, there are diurnal and age-related changes in H3K9me3 that coincide with changes in transcription.
conclusionsThe data suggest a model where some age-related changes in diurnal expression are partially attributed to age-related alterations to rhythmic facultative heterochromatin. The changes in heterochromatin are potentially mediated by changes in diurnal lncRNA creating an interlocked circadian-chromatin regulatory network that undergoes age-dependent metamorphosis.
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